2. Gene
  3. CYP11B1 - Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 Gene

CYP11B1 - Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Cp11ba; CYPXIB1; P450C11; RATCP11BA

基因 ID: 500892 | 基因类型: protein coding

关于 CYP11B1

功能概要

Enables steroid 11-beta-monooxygenase activity and steroid binding activity. Involved in several processes, including cellular response to interferon-gamma; primary alcohol biosynthetic process; and response to dexamethasone. Located in mitochondrion. Is integral component of endoplasmic reticulum membrane. Used to study hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (Cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (Cytochrome P450 family 11 subfamily B member 2). [provided by Alliance of Genome Resources, Apr 2022]

CYP11B1 基因产物(1)

mRNA Protein Name
NM_012537.3 NP_036669.3 cytochrome P450 11B1, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables steroid 11-beta-monooxygenase activity IDA
IDA: 通过直接分析推断
16405651 RGD
enables steroid binding IDA
IDA: 通过直接分析推断
16405651 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenosine metabolic process IEP
IEP: 通过表达模式推断
20937274 RGD
involved in aldosterone biosynthetic process IMP
IMP: 通过突变表型推断
19342457 RGD
involved in cellular response to type II interferon IEP
IEP: 通过表达模式推断
12121434 RGD
involved in cortisol biosynthetic process IMP
IMP: 通过突变表型推断
19342457 RGD
involved in dibenzo-p-dioxin metabolic process IEP
IEP: 通过表达模式推断
16254025 RGD
involved in glucocorticoid biosynthetic process IDA
IDA: 通过直接分析推断
19665544 RGD
involved in response to dexamethasone IEP
IEP: 通过表达模式推断
18252953 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
19733641 RGD
involved in steroid biosynthetic process IDA
IDA: 通过直接分析推断
16405651 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cytochrome P450 11B1, mitochondrial

Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase)

P450(11 beta)-DS

aldosterone synthase

cytochrome P450 11B1, mitochondrial-like

cytochrome P450(11 beta)-DS

cytochrome P450, subfamily 11B, polypeptide 1

cytochrome P450C11

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-16276 Osilodrostat Inhibitor 99.90% 是
HY-16276A Osilodrostat phosphate Inhibitor 99.35% 是
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-135794 11-Ketodihydrotestosterone Agonist 98.03% 否
HY-101217 BI 689648 Inhibitor 99.20% 否
HY-135281 CYP11B2-IN-1 Inhibitor 99.83% 否
HY-151140 CYP11B1-IN-2 Inhibitor / 否
HY-RS03435 CYP11B1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-163751 STING-IN-9 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens CYP11B1 NCBI NCBI:1584
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