PAEP - progestagen associated endometrial protein Gene

中文名称：孕激素相关子宫内膜蛋白

种属: Homo sapiens

同用名: GD; GdA; GdF; GdS; PEP; PAEG; PP14; ZIF-1

基因 ID: 5047 | 基因类型: protein coding

关于 PAEP

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:135,561,756-135,566,955 (from NCBI)

This gene has 9 transcripts (splice variants), 154 orthologues and 12 paralogues. Restricted expression toward endometrium (RPKM 125.9).

功能概要

该基因是内核脂质运载蛋白超家族的成员，其成员具有相对较低的序列相似性，但具有高度保守的外显子/内含子结构和三维蛋白质折叠。大多数脂质运载蛋白聚集在 9 号染色体的长臂上。编码的糖蛋白以前被称为妊娠相关子宫内膜 α-2 球蛋白、胎盘蛋白 14 和糖蛋白，但已正式命名为孕激素相关子宫内膜蛋白。在生殖系统的羊水、卵泡液和精浆中发现了三种不同的形式，具有相同的蛋白质主链但不同的糖基化特征。这些糖蛋白在调节适合怀孕的子宫环境以及在受精过程中适当事件顺序的时间安排和发生方面具有独特而重要的作用。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 10 月]

This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

PAEP 基因产物(3)

mRNA	Protein	Name
NM_001018048.2	NP_001018058.1	glycodelin isoform 2 precursor
NM_001018049.3	NP_001018059.1	glycodelin isoform 1 precursor
NM_002571.4	NP_002562.2	glycodelin isoform 1 precursor

PAEP 蛋白结构

Lipocalin

0
100
180 a.a.

蛋白主名

其他名称

glycodelin

PEG

重组 PAEP 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71669	PAEP Protein, Human (HEK293, Myc, His)	P09466-1 (M19-F180)	≥95%
HY-P700004	PAEP Protein, Human (HEK293, His)	P09466-1 (M19-F180)	≥95%

关联疾病

疾病名称

别名

Kleefstra Syndrome 1

9q Subtelomeric Deletion Syndrome	KLEFS1
Chromosome 9q34.3 Deletion Syndrome	9q- Syndrome
9q34 Deletion Syndrome	Kleefstra Syndrome Due To 9q34 Microdeletion
Kleefstra Syndrome	9q-Syndrome
9qstds	Kleefstra Syndrome Due To 9q Subtelomeric Deletion
Kleefstra Syndrome Due To Del(9)(Q34)	Kleefstra Syndrome Due To Monosomy 9q34
Chromosome 9q Subtelomeric Deletion Syndrome	Kleefstra Syndrome, Type 1

Ectopic Pregnancy

Eccyesis	Pregnancy Ectopic
Pregnancy, Ectopic	Ectopic Pregnancies
Extrauterine Gestation Or Pregnancy	Extrauterine Pregnancy
Ep - [Ectopic Pregnancy]	Ectopic Mole
Aborted Ectopic Pregnancy	Ruptured Ectopic Pregnancy

Submucous Uterine Fibroid

Submucous Leiomyoma Of Uterus

Ovarian Cyst

Ovarian Cysts

Endometriosis

Endometriosis, Site Unspecified

Endometrial Ectopia

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Pregnancy Loss, Recurrent 1

Pregnancy Loss, Recurrent, Susceptibility To, 1	Rpl
RPRGL1	Rprgl
Recurrent Miscarriage	Recurrent Spontaneous Abortion
Abortion, Spontaneous, Recurrent	Fetal Loss, Recurrent
Fetal Loss, Recurrent, Susceptibility To	Miscarriage, Recurrent
Embryonic Loss, Recurrent	Stillbirth, Recurrent
Pregnancy Loss, Recurrent, 1	Recurrent Embryonic Loss
Recurrent Fetal Loss	Recurrent Stillbirth
Spontaneous Recurrent Abortion	Miscarriage Recurrent
Pregnancy Loss, Recurrent, Susceptibility To, Type 1	Abortion, Habitual

Infertility

Microphthalmia, Isolated 4

Isolated Microphthalmia 4	MCOP4
Microphthalmia, Isolated, 4	Isolated Clinical Anophthalmia
Microphthalmia, Isolated, Type 4

Brachydactyly, Type A1, C

Brachydactyly Type A1c	BDA1C
Brachydactyly A1, C	Brachydactyly A1c
Brachydactyly Type A1 C

Atypical Follicular Adenoma

Multiple Synostoses Syndrome

Symphalangism-Brachydactyly Syndrome	Deafness-Hermann Type Symphalangism Syndrome
Facio-Audio-Symphalangism	Hearing Loss-Hermann Type Symphalangism Syndrome
Wl Syndrome	Multiple Synostosis Syndrome

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1

Eec Syndrome	Rudiger Syndrome 1
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1	EEC1
Eec Syndrome 1	Eec Syndrome-1
Walker-Clodius Syndrome	Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome
Eec	Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome
Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome	Ectrodactyly-Cleft Lip/Palate Syndrome
Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate	Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome
Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome	Ectrodactyly-Cleft Lip-Palate Syndrome
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome

Proximal Symphalangism

Cushing'S Symphalangism	Symphalangism, Proximal
Hereditary Absence Of Proximal Interphalangeal Joints	Strasburger-Hawkins-Eldridge Syndrome
Strasburger-Hawkins-Eldridge-Hargrave-Mckusick Syndrome	Symphalangism, Proximal, 1a
Symphalangism, Proximal, 1b	Vessel'S Syndrome
Symphalangism, Cushing Type

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Acromesomelic Dysplasia 2b

Fibular Hypoplasia And Complex Brachydactyly	Du Pan Syndrome
AMD2B	Dupans
Acromesomelic Dysplasia-2b	Fibular Aplasia-Complex Brachydactyly Syndrome

Brachydactyly, Type C

Brachydactyly Type C	BDC
Brachydactyly Haws Type	Brachydactyly, Haws Type
Brachydactyly C

Brachydactyly, Type A2

Brachydactyly Type A2	BDA2
Mohr-Wriedt Type Brachydactyly	Brachymesophalangy Ii
Brachymesophalangy Type 2	Brachymesophalangy 2
Brachydactyly, Mohr-Wriedt Type	Brachydactyly A2

Infiltrating Angiolipoma

Angiolipoma, Infiltrating

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09965	PAEP Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PAEP	RGD	RGD:2293817
Others	PAEP	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

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PAEP - progestagen associated endometrial protein Gene

关于 PAEP

功能概要

PAEP 基因产物(3)

PAEP 蛋白结构

重组 PAEP 蛋白

关联疾病

直系同源

热门区域

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PAEP - progestagen associated endometrial protein Gene

关于 PAEP

功能概要

PAEP 基因产物(3)

PAEP 蛋白结构

重组 PAEP 蛋白

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z