PAWR - pro-apoptotic WT1 regulator Gene

中文名称：促凋亡 WT1 调节因子

种属: Homo sapiens

同用名: PAR4; Par-4

基因 ID: 5074 | 基因类型: protein coding

关于 PAWR

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:79,584,879-79,690,964 (from NCBI)

This gene has 11 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in endometrium (RPKM 8.7), thyroid (RPKM 5.9) and 24 other tissues.

功能概要

该基因编码一种肿瘤抑制蛋白，可通过细胞内和细胞外机制选择性地诱导癌细胞凋亡。细胞内机制涉及抑制促存活途径和激活 Fas 介导的细胞凋亡，而细胞外机制涉及该蛋白的分泌形式与细胞表面的葡萄糖调节蛋白 78 (GRP78) 结合，从而导致外源性凋亡途径的激活。该基因位于不稳定的人类染色体 12q21 区域，在不同肿瘤中经常发生缺失或突变。编码的蛋白质在与年龄相关的疾病的进展中也起着重要作用。[RefSeq 提供，2017 年 8 月]

This gene encodes a tumor suppressor protein that selectively induces Apoptosis in Cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated Apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]

PAWR 基因产物(3)

mRNA	Protein	Name
NM_001354732.2	NP_001341661.1	PRKC apoptosis WT1 regulator protein isoform 1
NM_001354733.2	NP_001341662.1	PRKC apoptosis WT1 regulator protein isoform 2
NM_002583.4	NP_002574.2	PRKC apoptosis WT1 regulator protein isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme binding	IDA IDA: 通过直接分析推断	15671026	GOA
enables leucine zipper domain binding	IPI IPI: 通过物理相互作用推断	14627703	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11755531	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	14627703	GOA
located in nucleus	IDA IDA: 通过直接分析推断	14627703	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

PRKC apoptosis WT1 regulator protein

PRKC, apoptosis, WT1, regulator

PAWR 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PAWR	Q96IZ0	SPSB4	Homo sapiens	Q96A44	ITC	20561531
种属内	PAWR	Q96IZ0	SPSB1	Homo sapiens	Q96BD6	X-Ray Diffraction	20561531
种属内	PAWR	Q96IZ0	VIM	Homo sapiens	P08670	Anti Bait CoIP	25218743
种属内	PAWR	Q96IZ0	HSPA5	Homo sapiens	P11021	Anti Tag CoIP	19632185
种属内	PAWR	Q96IZ0	HSPA5	Homo sapiens	P11021	Anti Bait CoIP	19632185
种属内	PAWR	Q96IZ0	HSPA5	Homo sapiens	P11021	IF	19632185
种属间	PAWR	Q96IZ0	Spsb2	Mus musculus	O88838	Anti Bait CoIP	16369487
种属间	PAWR	Q96IZ0	Spsb2	Mus musculus	O88838	ITC	20561531
种属间	PAWR	Q96IZ0	Spsb2	Mus musculus	O88838	NMR	20561531
种属间	PAWR	Q96IZ0	Spsb1	Mus musculus	Q9D5L7	ITC	20561531
种属间	PAWR	Q96IZ0	Spsb4	Mus musculus	Q8R5B6	ITC	20561531

种属间: 跨种属相互作用 种属内: 同种属相互作用

PAWR 抗体

目录号	产品名	应用	反应物种
HY-P82858	PAR4 Antibody (YA2603)	WB	Human, Mouse, Rat
HY-P85314	PAR4 Antibody (YA5006)	WB, IHC-P, ICC/IF, ELISA	Human

关联疾病

疾病名称

别名

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Gapo Syndrome

GAPOS	Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy
Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome	Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10087	PAWR Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21400	Pawr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PAWR	RGD	RGD:69065
Bos taurus	PAWR	VGNC	VGNC:106857
Mus musculus	PAWR	MGD	MGI:2149961
Macaca mulatta	PAWR	VGNC	VGNC:75759

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PAWR - pro-apoptotic WT1 regulator Gene

关于 PAWR

功能概要

PAWR 基因产物(3)

PAWR 蛋白互作信息

PAWR 抗体

关联疾病

直系同源

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PAWR - pro-apoptotic WT1 regulator Gene

关于 PAWR

功能概要

PAWR 基因产物(3)

PAWR 蛋白互作信息

PAWR 抗体

关联疾病

相关产品

直系同源

热门区域

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F

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