2. Gene
  3. Magi2 - membrane associated guanylate kinase, WW and PDZ domain containing 2 Gene

Magi2 - membrane associated guanylate kinase, WW and PDZ domain containing 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: AIP-1; Acvri1; Magi-2; S-SCAM; Acvrip1; Acvrinp1; mKIAA0705

基因 ID: 50791 | 基因类型: protein coding

关于 Magi2

功能概要

Enables SMAD binding activity and type II activin receptor binding activity. Involved in several processes, including SMAD protein signal transduction; neuroligin clustering involved in postsynaptic membrane assembly; and positive regulation of synaptic vesicle clustering. Acts upstream of or within signal transduction. Located in cytoplasm; dendrite; and plasma membrane. Is expressed in several structures, including branchial arch; genitourinary system; limb; nervous system; and vibrissa. Used to study schizophrenia. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Magi2 基因产物(3)

mRNA Protein Name
NM_001170745.1 NP_001164216.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 3
NM_001170746.1 NP_001164217.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 1
NM_015823.3 NP_056638.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SMAD binding IPI
IPI: 通过物理相互作用推断
10681527 MGI
enables activin receptor binding IPI
IPI: 通过物理相互作用推断
10681527 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14529612 MGI
enables type II activin receptor binding IPI
IPI: 通过物理相互作用推断
16648306 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in SMAD protein signal transduction IDA
IDA: 通过直接分析推断
10681527 MGI
involved in clathrin-dependent endocytosis IMP
IMP: 通过突变表型推断
24608321 MGI
involved in negative regulation of activin receptor signaling pathway IDA
IDA: 通过直接分析推断
10681527 MGI
involved in neuroligin clustering involved in postsynaptic membrane assembly IDA
IDA: 通过直接分析推断
20534458 MGI
involved in positive regulation of synaptic vesicle clustering IDA
IDA: 通过直接分析推断
20534458 MGI
acts upstream of or within signal transduction IPI
IPI: 通过物理相互作用推断
10681527 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centriole IDA
IDA: 通过直接分析推断
24608321 MGI
located in ciliary base IDA
IDA: 通过直接分析推断
24608321 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
16870733 MGI
located in dendrite IDA
IDA: 通过直接分析推断
20534458 MGI
located in photoreceptor inner segment IDA
IDA: 通过直接分析推断
24608321 MGI
located in photoreceptor outer segment IDA
IDA: 通过直接分析推断
24608321 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
16870733 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

activin receptor interacting protein 1

atrophin-1-interacting protein 1

membrane-associated guanylate kinase inverted 2

Magi2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Magi2 Q9WVQ1 Dll1 Mus musculus Q61483
Y2H
14529612
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07982 MAGI2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22622 Magi2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Magi2 NCBI NCBI:9863
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