2. Gene
  3. Prkn - parkin RBR E3 ubiquitin protein ligase Gene

Prkn - parkin RBR E3 ubiquitin protein ligase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Park2

基因 ID: 50873 | 基因类型: protein coding

关于 Prkn

功能概要

Enables ubiquitin protein Ligase activity. Involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway; positive regulation of cellular protein metabolic process; and positive regulation of dendrite extension. Acts upstream of or within several processes, including Catecholamine metabolic process; chemical synaptic transmission; and Mitophagy. Located in mitochondrion; neuron projection; and nucleus. Part of protein-containing complex. Is expressed in several structures, including face; nervous system; pancreas; sensory organ; and skeleton. Used to study Parkinson's disease 2. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; and ovarian Cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Prkn 基因产物(3)

mRNA Protein Name
NM_001317726.2 NP_001304655.1 E3 ubiquitin-protein ligase parkin isoform 2
NM_001403470.1 NP_001390399.1 E3 ubiquitin-protein ligase parkin isoform 3
NM_016694.5 NP_057903.1 E3 ubiquitin-protein ligase parkin isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12628165 MGI
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
20064468 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adult locomotory behavior IMP
IMP: 通过突变表型推断
18346797 MGI
involved in cellular response to toxic substance IDA
IDA: 通过直接分析推断
12628165 MGI
NOT acts upstream of or within dopamine metabolic process IMP
IMP: 通过突变表型推断
15684050 MGI
acts upstream of or within dopamine metabolic process IMP
IMP: 通过突变表型推断
12915482 MGI
acts upstream of or within dopamine uptake involved in synaptic transmission IMP
IMP: 通过突变表型推断
12915482 MGI
NOT acts upstream of or within learning IMP
IMP: 通过突变表型推断
15684050 MGI
acts upstream of or within learning IMP
IMP: 通过突变表型推断
12915482 MGI
NOT acts upstream of or within locomotory behavior IMP
IMP: 通过突变表型推断
15684050 MGI
acts upstream of or within locomotory behavior IMP
IMP: 通过突变表型推断
12915482 MGI
acts upstream of or within mitophagy IGI
IGI: 通过遗传相互作用推断
24949970 MGI
acts upstream of or within modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
12930822 MGI
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
21113145 MGI
involved in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
17116640 MGI
involved in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
23453807 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
12628165 MGI
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
23858059 MGI
acts upstream of or within norepinephrine metabolic process IMP
IMP: 通过突变表型推断
15249681 MGI
involved in positive regulation of dendrite extension IGI
IGI: 通过遗传相互作用推断
24898855 MGI
involved in positive regulation of protein linear polyubiquitination IMP
IMP: 通过突变表型推断
23453807 MGI
involved in protein catabolic process IMP
IMP: 通过突变表型推断
21376232 MGI
involved in protein destabilization IMP
IMP: 通过突变表型推断
19591802 MGI
involved in protein localization to mitochondrion IMP
IMP: 通过突变表型推断
23858059 MGI
acts upstream of or within protein metabolic process IMP
IMP: 通过突变表型推断
14985362 MGI
involved in regulation of mitochondrial membrane potential IGI
IGI: 通过遗传相互作用推断
24898855 MGI
acts upstream of or within regulation of neurotransmitter secretion IMP
IMP: 通过突变表型推断
12930822 MGI
involved in regulation of synaptic vesicle endocytosis IDA
IDA: 通过直接分析推断
29311685 MGI
involved in regulation of synaptic vesicle endocytosis IEP
IEP: 通过表达模式推断
29311685 MGI
involved in regulation of synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
29311685 MGI
involved in regulation protein catabolic process at presynapse IDA
IDA: 通过直接分析推断
29311685 MGI
involved in regulation protein catabolic process at presynapse IEP
IEP: 通过表达模式推断
29311685 MGI
involved in regulation protein catabolic process at presynapse IMP
IMP: 通过突变表型推断
29311685 MGI
involved in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
21113145 MGI
acts upstream of or within startle response IMP
IMP: 通过突变表型推断
15249681 MGI
acts upstream of or within synaptic transmission, dopaminergic IMP
IMP: 通过突变表型推断
12915482 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
12915482 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
24187134 MGI
is active in dopaminergic synapse IDA
IDA: 通过直接分析推断
29311685 MGI
is active in dopaminergic synapse IEP
IEP: 通过表达模式推断
29311685 MGI
is active in dopaminergic synapse IMP
IMP: 通过突变表型推断
29311685 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
23858059 MGI
located in neuron projection IDA
IDA: 通过直接分析推断
11675120 MGI
located in nucleus IDA
IDA: 通过直接分析推断
24187134 MGI
part of protein-containing complex IDA
IDA: 通过直接分析推断
18190519 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

E3 ubiquitin-protein ligase parkin

Parkinson disease (autosomal recessive, juvenile) 2, parkin

parkin protein

Prkn 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Prkn Q9WVS6 Ywhah Mus musculus P68510
Anti Bait CoIP
16096643
种属内
Prkn Q9WVS6 Ranbp2 Mus musculus Q9ERU9
Anti Bait CoIP
16332688
种属内
Prkn Q9WVS6 Chpf Mus musculus Q6IQX7-2
IF
22082830
种属内
Prkn Q9WVS6 Chpf Mus musculus Q6IQX7-2
Anti Bait CoIP
22082830
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11156 PRKN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18966 Prkn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25456 Prkn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkn NCBI NCBI:5071
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