PCK1 - phosphoenolpyruvate carboxykinase 1 Gene

中文名称：磷酸烯醇丙酮酸羧激酶 1

种属: Homo sapiens

同用名: PCKDC; PEPCK1; PEPCKC; PEPCK-C

基因 ID: 5105 | 基因类型: protein coding

关于 PCK1

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:57,561,110-57,568,121 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues, 1 paralogue and is associated with 2 phenotypes. Biased expression in liver (RPKM 471.7), kidney (RPKM 448.1) and 4 other tissues.

功能概要

该基因是调节糖异生的主要控制点。由该基因编码的胞质酶与 GTP 一起催化草酰乙酸形成磷酸烯醇丙酮酸，同时释放二氧化碳和 GDP。该基因的表达可以通过胰岛素、糖皮质激素、胰高血糖素、cAMP 和饮食进行调节。该基因的缺陷是细胞溶质磷酸烯醇丙酮酸羧激酶缺乏症的原因。所编码蛋白质的线粒体同功酶也已被表征。[RefSeq 提供，2008 年 7 月]

This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by Insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]

PCK1 基因产物(1)

mRNA	Protein	Name
NM_002591.4	NP_002582.3	phosphoenolpyruvate carboxykinase, cytosolic [GTP]

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTP binding	IDA IDA: 通过直接分析推断	11851336	GOA
enables carboxylic acid binding	IDA IDA: 通过直接分析推断	11851336	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	11851336	GOA
enables manganese ion binding	IDA IDA: 通过直接分析推断	11851336	GOA
enables phosphoenolpyruvate carboxykinase (GTP) activity	EXP EXP: 通过实验结果推断	11851336	GOA
enables phosphoenolpyruvate carboxykinase (GTP) activity	IDA IDA: 通过直接分析推断	30193097	GOA
enables phosphoenolpyruvate carboxykinase (GTP) activity	IMP IMP: 通过突变表型推断	26971250	GOA
enables protein serine kinase activity (using GTP as donor)	IDA IDA: 通过直接分析推断	32322062	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to glucose stimulus	IDA IDA: 通过直接分析推断	30193097	GOA
involved in cellular response to insulin stimulus	IDA IDA: 通过直接分析推断	32322062	GOA
involved in gluconeogenesis	IDA IDA: 通过直接分析推断	30193097	GOA
involved in gluconeogenesis	IMP IMP: 通过突变表型推断	26971250	GOA
involved in glucose metabolic process	IMP IMP: 通过突变表型推断	14764811	GOA
involved in oxaloacetate metabolic process	IDA IDA: 通过直接分析推断	30193097	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	32322062	GOA
involved in positive regulation of lipid biosynthetic process	IDA IDA: 通过直接分析推断	32322062	GOA
involved in regulation of lipid biosynthetic process	IDA IDA: 通过直接分析推断	32322062	GOA
involved in response to insulin	IDA IDA: 通过直接分析推断	14764811	GOA
involved in tricarboxylic acid metabolic process	IDA IDA: 通过直接分析推断	30193097	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	32322062	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	32322062	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PCK1 蛋白结构

PEPCK_C

0
100
200
300
400
500
622 a.a.

蛋白主名

其他名称

phosphoenolpyruvate carboxykinase, cytosolic [GTP]

PEP carboxykinase

PCK1 抗体

目录号	产品名	应用	反应物种
HY-P80267	PCK1 Antibody (YA242)	ICC/IF, IHC-P, WB	Human

关联疾病

疾病名称

别名

Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic

PCKDC	Pck1 Deficiency, Cytosolic
Pepck Deficiency, Cytosolic	Deficiency, Phosphoenolpyruvate Carboxykinase, Cytosolic

Pepck 1 Deficiency

Phosphoenolpyruvate Carboxykinase Deficiency	Phosphoenolpyruvate Carboxykinase Deficiency
Pep Carboxykinase Deficiency	Phosphoenolpyruvate Carboxykinase-1 Deficiency
Phosphoenolpyruvate Carboxylase Deficiency	Phosphopyruvate Carboxylase Deficiency
Pepck Deficiency

Hypoglycemia

Hypoglycaemia	Low Blood Sugar
Hypoglycaemia Nos	Spontaneous Hypoglycaemia
Nondiabetic Hypoglycaemia	Hypoglycaemic Disorder Nos
Hypoglycaemic Syndrome

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Smith-Magenis Syndrome

SMS	Chromosome 17p11.2 Deletion Syndrome
17p11.2 Microdeletion Syndrome	17p11.2 Monosomy
Chromosome 17p Deletion Syndrome	Del(17)
P11.2	17p- Syndrome
Deletion 17p Syndrome	Partial Monosomy 17p

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Diabetes Mellitus

Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10152	PCK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17590	Pck1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24050	Pck1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PCK1	MGD	MGI:97501
Canis familiaris	PCK1	VGNC	VGNC:44307
Macaca mulatta	PCK1	VGNC	VGNC:75779
Felis catus	PCK1	VGNC	VGNC:68726
Bos taurus	PCK1	VGNC	VGNC:32631
Rattus norvegicus	PCK1	RGD	RGD:3267

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PCK1 - phosphoenolpyruvate carboxykinase 1 Gene

关于 PCK1

功能概要

PCK1 基因产物(1)

PCK1 蛋白结构

PCK1 抗体

关联疾病

直系同源

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PCK1 - phosphoenolpyruvate carboxykinase 1 Gene

关于 PCK1

功能概要

PCK1 基因产物(1)

PCK1 蛋白结构

PCK1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z