2. Gene
  3. ZDHHC9 - zinc finger DHHC-type palmitoyltransferase 9 Gene

ZDHHC9 - zinc finger DHHC-type palmitoyltransferase 9 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：锌指 DHHC 型棕榈酰转移酶 9

种属: Homo sapiens

同用名: CGI89; DHHC9; MMSA1; MRXSR; MRXSZ; ZNF379; ZNF380; CXorf11; ZDHHC10

基因 ID: 51114 | 基因类型: protein coding

关于 ZDHHC9

Cytogenetic location: Xq26.1 Genomic coordinates (GRCh38): X:129,803,288-129,843,886 (from NCBI)

This gene has 5 transcripts (splice variants), 213 orthologues, 17 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 17.9), kidney (RPKM 10.5) and 25 other tissues.

功能概要

该基因编码一种完整的膜蛋白，它是包含锌指 DHHC 结构域的蛋白家族的成员。编码的蛋白质与 golgin 亚家族 A 成员 7 形成复合物，并起棕榈酰转移酶的作用。这种蛋白质特异性棕榈酰化 HRAS 和 NRAS。该基因的突变与 X 连锁认知障碍有关。交替剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2010 年 5 月]

This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010]

ZDHHC9 基因产物(2)

mRNA Protein Name
NM_001008222.3 NP_001008223.1 palmitoyltransferase ZDHHC9
NM_016032.4 NP_057116.2 palmitoyltransferase ZDHHC9
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Ras palmitoyltransferase activity IDA
IDA: 通过直接分析推断
16000296 GOA
enables palmitoyltransferase activity IDA
IDA: 通过直接分析推断
23034182 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25910212 GOA
enables protein-cysteine S-palmitoyltransferase activity IDA
IDA: 通过直接分析推断
37802025 GOA
enables protein-cysteine S-palmitoyltransferase activity IMP
IMP: 通过突变表型推断
34599882 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in peptidyl-L-cysteine S-palmitoylation IDA
IDA: 通过直接分析推断
16000296 GOA
involved in peptidyl-L-cysteine S-palmitoylation IMP
IMP: 通过突变表型推断
27481942 GOA
involved in positive regulation by host of viral process IDA
IDA: 通过直接分析推断
34599882 GOA
involved in positive regulation by host of viral process IMP
IMP: 通过突变表型推断
34599882 GOA
involved in positive regulation of cGAS/STING signaling pathway IDA
IDA: 通过直接分析推断
37802025 GOA
involved in positive regulation of pyroptotic inflammatory response IDA
IDA: 通过直接分析推断
38530158 GOA
involved in protein palmitoylation IDA
IDA: 通过直接分析推断
23034182 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
16647879 GOA
located in Golgi membrane IDA
IDA: 通过直接分析推断
16000296 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
16000296 GOA
part of palmitoyltransferase complex IDA
IDA: 通过直接分析推断
16000296 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZDHHC9 蛋白结构

DHHC

DHHC: DHHC palmitoyltransferase (82 - 261)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
蛋白主名 其他名称

palmitoyltransferase ZDHHC9

Asp-His-His-Cys domain containing protein 9

ZDHHC9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZDHHC9 Q9Y397 CREB3 Homo sapiens O43889-2
Validated Y2H
25910212
种属内
ZDHHC9 Q9Y397 CREB3 Homo sapiens O43889-2
Y2H Array
25910212
种属内
ZDHHC9 Q9Y397 CREB3 Homo sapiens O43889-2
Y2H Bait-Prey Pool
25910212
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, X-Linked, Syndromic, Raymond Type

MRXSR

Syndromic X-Linked Intellectual Disability Raymond Type

Mental Retardation, X-Linked, Syndromic, Raymond Type

Mental Retardation, X-Linked Syndromic, Raymond Type

Intellectual Developmental Disorder, X-Linked Syndromic, Raymond Type

X-Linked Syndromic Intellectual Developmental Disorder Raymond Type
Intellectual Developmental Disorder, X-Linked, Syndromic, Lujan-Fryns Type

Lujan-Fryns Syndrome

X-Linked Intellectual Disability With Marfanoid Habitus

MRXSLF

Mental Retardation, X-Linked, With Marfanoid Habitus, 1
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome

Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

Syndactyly With Renal And Anogenital Malformations

STAR

Syndactyly, Telecanthus, Anogenital And Renal Malformations

Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy

Benign Rolandic Epilepsy

Epilepsy, Rolandic

Bcects

Benign Childhood Epilepsy With Centrotemporal Spike

Sylvan Seizures

Becrs

Bects

Bre

Benign Epilepsy Of Childhood With Centrotemporal Spikes

Benign Familial Epilepsy Of Childhood With Rolandic Spikes

Centrotemporal Epilepsy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-155938 Cyano-myracrylamide Inhibitor 98.13% Phase 3
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16024 ZDHHC9 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ZDHHC9 VGNC VGNC:37146
Felis catus ZDHHC9 VGNC VGNC:67220
Canis familiaris ZDHHC9 VGNC VGNC:48595
Mus musculus ZDHHC9 MGD MGI:2444393
Macaca mulatta ZDHHC9 VGNC VGNC:79147
Rattus norvegicus ZDHHC9 RGD RGD:1561389
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