PCOLCE - procollagen C-endopeptidase enhancer Gene

中文名称：前胶原 C-内肽酶增强因子

种属: Homo sapiens

同用名: PCPE; PCPE1; PCPE-1

基因 ID: 5118 | 基因类型: protein coding

关于 PCOLCE

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,602,363-100,608,175 (from NCBI)

This gene has 10 transcripts (splice variants), 246 orthologues and 35 paralogues. Ubiquitous expression in gall bladder (RPKM 64.6), endometrium (RPKM 44.2) and 21 other tissues.

功能概要

I-III 型纤维胶原蛋白作为前体分子合成，称为前胶原。这些前体包含氨基和羧基末端的肽延伸，分别称为 N- 和 C- 前肽，它们在细胞分泌前胶原时被切割，产生成熟的三螺旋、高度结构化的原纤维。该基因编码一种糖蛋白，该糖蛋白结合并驱动 I 型原胶原的酶促裂解并提高 C 蛋白酶活性。[RefSeq 提供，2008 年 7 月]

Fibrillar Collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008]

PCOLCE 基因产物(1)

mRNA	Protein	Name
NM_002593.4	NP_002584.2	procollagen C-endopeptidase enhancer 1 precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables collagen binding	IDA IDA: 通过直接分析推断	12393877	GOA
enables heparin binding	IDA IDA: 通过直接分析推断	12393877	GOA
enables peptidase activator activity	IDA IDA: 通过直接分析推断	12393877	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20207734	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PCOLCE 蛋白结构

CUB

NTR

0
100
200
300
400
449 a.a.

蛋白主名

其他名称

procollagen C-endopeptidase enhancer 1

procollagen C-proteinase enhancer 1	procollagen COOH-terminal proteinase enhancer 1
procollagen, type 1, COOH-terminal proteinase enhancer	type 1 procollagen C-proteinase enhancer protein
type I procollagen COOH-terminal proteinase enhancer

PCOLCE 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	PCOLCE	Q15113	Sdc2	Mus musculus	P43407	Solid Phase Assay	25286301
种属间	PCOLCE	Q15113	Sdc2	Mus musculus	P43407	Anti Bait CoIP	25286301
种属内	PCOLCE	Q15113	THBS1	Homo sapiens	P07996	SPR Array	24117177
种属内	PCOLCE	Q15113	P39060-PRO_0000005794	Homo sapiens	P39060-PRO_0000005794	Anti Bait CoIP	24117177
种属内	PCOLCE	Q15113	P39060-PRO_0000005794	Homo sapiens	P39060-PRO_0000005794	SPR Array	24117177
种属内	PCOLCE	Q15113	BMP1	Homo sapiens	P13497	SPR	20207734
种属内	PCOLCE	Q15113	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	SPR Array	24117177
种属间	PCOLCE	Q15113	Sdc1	Mus musculus	P18828	Anti Bait CoIP	25286301
种属间	PCOLCE	Q15113	Sdc4	Mus musculus	O35988	Anti Bait CoIP	25286301
种属间	PCOLCE	Q15113	FN1	Bos taurus	P07589	Solid Phase Assay	25286301
种属间	PCOLCE	Q15113	FN1	Bos taurus	P07589	Anti Bait CoIP	25286301

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Osteogenesis Imperfecta, Type Iii

Osteogenesis Imperfecta Type Iii	OI3
Oi, Type Iii	Osteogenesis Imperfecta Type 3
Oi Type 3	Oi Type Iii
Progressive Deforming Osteogenesis Imperfecta	Severe Osteogenesis Imperfecta
Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae	Progressively Deforming Osteogenesis Imperfecta With Normal Sclera
Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae	Progressively Deforming Oi
Osteogenesis Imperfecta 3	Oi-Iii
Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae

Alacrima, Achalasia, And Mental Retardation Syndrome

AAMR	Alacrima, Achalasia, And Intellectual Disability Syndrome
Alacrima, Achalasia, And Impaired Intellectual Development Syndrome	Intellectual Disability

Stickler Syndrome, Type I

Stickler Syndrome 1	Stickler Syndrome Type 1
STL1	Aom
Stickler Syndrome, Type 1	Stickler Syndrome, Vitreous Type 1
Stickler Syndrome, Membranous Vitreous Type	Arthroophthalmopathy, Hereditary Progressive
Arthro-Ophthalmopathy Hereditary Progressive	Stickler Syndrome Membranous Vitreous Type
Stickler Syndrome Type I	Stickler Syndrome Vitreous Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10163	PCOLCE Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS10164	Pcolce Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS10165	Pcolce Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS10166	PCOLCE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21248	Pcolce2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27765	Pcolce2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	PCOLCE	VGNC	VGNC:44316
Rattus norvegicus	PCOLCE	RGD	RGD:3270
Felis catus	PCOLCE	VGNC	VGNC:68729
Macaca mulatta	PCOLCE	VGNC	VGNC:75782
Mus musculus	PCOLCE	MGD	MGI:105099
Bos taurus	PCOLCE	VGNC	VGNC:32642

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PCOLCE - procollagen C-endopeptidase enhancer Gene

关于 PCOLCE

功能概要

PCOLCE 基因产物(1)

PCOLCE 蛋白结构

PCOLCE 蛋白互作信息

关联疾病

直系同源

热门区域

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PCOLCE - procollagen C-endopeptidase enhancer Gene

关于 PCOLCE

功能概要

PCOLCE 基因产物(1)

PCOLCE 蛋白结构

PCOLCE 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z