2. Gene
  3. PLA1A - phospholipase A1 member A Gene

PLA1A - phospholipase A1 member A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷脂酶 A1 成员 A

种属: Homo sapiens

同用名: PSPLA1; PS-PLA1

基因 ID: 51365 | 基因类型: protein coding

关于 PLA1A

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:119,597,885-119,629,811 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 9 paralogues. Broad expression in liver (RPKM 8.5), lymph node (RPKM 6.1) and 17 other tissues.

功能概要

该基因编码的蛋白质是一种磷脂酶，可水解磷脂酰丝氨酸和 1-酰基-2-溶血磷脂酰丝氨酸 sn-1 位的脂肪酸。这种分泌的蛋白质水解脂质体中的磷脂酰丝氨酸。已发现该基因编码不同亚型的三种转录变体。[RefSeq 提供，2011 年 5 月]

The protein encoded by this gene is a Phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

PLA1A 基因产物(4)

mRNA Protein Name
NM_001206960.2 NP_001193889.1 phospholipase A1 member A isoform 2 precursor
NM_001206961.2 NP_001193890.1 phospholipase A1 member A isoform 3
NM_001293225.2 NP_001280154.1 phospholipase A1 member A isoform 4
NM_015900.4 NP_056984.1 phospholipase A1 member A isoform 1 precursor

PLA1A 蛋白结构

Lipase

Lipase: Lipase (17 - 336)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 456 a.a.
蛋白主名 其他名称

phospholipase A1 member A

phosphatidylserine-specific phospholipase A1alpha

关联疾病

疾病名称 别名
Orofacial Cleft 8

OFC8

Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 8

Non-Syndromic Cleft Lip/Palate 8

Non-Syndromic Cleft Lip With Or Without Cleft Palate 8

Orofacial Cleft, Type 8
Powassan Encephalitis

Powassan Encephalitis Virus Infection
Familial Woolly Hair Syndrome

Wooly Hair

Familial Wooly Hair Syndrome

Hereditary Woolly Hair Syndrome

Hereditary Wooly Hair Syndrome

Woolly Hair

Syndrome With Woolly Hair

Wooly Hair Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10615 PLA1A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17852 Lypla1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21024 Pla1a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24321 Lypla1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27541 Pla1a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PLA1A RGD RGD:621261
Bos taurus PLA1A VGNC VGNC:32953
Canis familiaris PLA1A VGNC VGNC:44619
Macaca mulatta PLA1A VGNC VGNC:76051
Mus musculus PLA1A MGD MGI:1934677
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