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  2. PPME1 - protein phosphatase methylesterase 1 Gene

PPME1 - protein phosphatase methylesterase 1 Gene

中文名称:蛋白磷酸酶甲酯酶 1

种属: Homo sapiens

同用名: PME-1; ABDH19

基因 ID: 51400 | 基因类型: protein coding

关于 PPME1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,171,289-74,254,703 (from NCBI)

This gene has 9 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in testis (RPKM 18.8), brain (RPKM 17.5) and 25 other tissues.

功能概要

该基因编码定位于细胞核的蛋白磷酸酶甲酯酶。编码的蛋白质作用于蛋白磷酸酶 2A 催化亚基,并通过调节蛋白的去磷酸化支持 ERK 通路。它在恶性神经胶质瘤进展中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供,2012 年 10 月]

This gene encodes a protein Phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

PPME1 基因产物(2)

mRNA Protein Name
NM_001271593.2 NP_001258522.1 protein phosphatase methylesterase 1 isoform b
NM_016147.3 NP_057231.1 protein phosphatase methylesterase 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein C-terminal methylesterase activity IDA
IDA: 通过直接分析推断
10318862 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22167190 GOA
enables protein phosphatase 2A binding IDA
IDA: 通过直接分析推断
10318862 GOA
enables protein phosphatase binding IDA
IDA: 通过直接分析推断
10318862 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein demethylation IDA
IDA: 通过直接分析推断
10318862 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PPME1 蛋白结构

Abhydrolase_6

Abhydrolase_6: Alpha/beta hydrolase family (79 - 362)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
蛋白主名 其他名称

protein phosphatase methylesterase 1

testicular secretory protein Li 39

关联疾病

疾病名称 别名
Alzheimer Disease 15

AD15

Alzheimer'S Disease 15

Alzheimer Disease Without Neurofibrillary Tangles

Alzheimer'S Disease 15, Late Onset

Alzheimer'S Disease Without Neurofibrillary Tangles

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PPME1 RGD RGD:1309683
Macaca mulatta PPME1 VGNC VGNC:76345
Mus musculus PPME1 MGD MGI:1919840
Felis catus PPME1 VGNC VGNC:64316
Canis familiaris PPME1 VGNC VGNC:44873
Bos taurus PPME1 VGNC VGNC:33218