2. Gene
  3. LIMA1 - LIM domain and actin binding 1 Gene

LIMA1 - LIM domain and actin binding 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：LIM 域和肌动蛋白结合 1

种属: Homo sapiens

同用名: EPLIN; LDLCQ8; SREBP3

基因 ID: 51474 | 基因类型: protein coding

关于 LIMA1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,175,788-50,283,520 (from NCBI)

This gene has 16 transcripts (splice variants), 222 orthologues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 57.9), small intestine (RPKM 51.2) and 23 other tissues.

功能概要

该基因编码一种细胞骨架相关蛋白，可抑制肌动蛋白丝解聚并使纤维束交联。它在一些癌细胞系中被下调。编码不同同种型的选择性剪接转录变体已被描述为该基因，并且一些变体的表达可能被独立调节。[RefSeq 提供，2011 年 8 月]

This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some Cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]

LIMA1 基因产物(12)

mRNA Protein Name
NM_001113546.2 NP_001107018.1 LIM domain and actin-binding protein 1 isoform 1
NM_001113547.2 NP_001107019.1 LIM domain and actin-binding protein 1 isoform 3
NM_001243775.2 NP_001230704.1 LIM domain and actin-binding protein 1 isoform 4
NM_001394886.1 NP_001381815.1 LIM domain and actin-binding protein 1 isoform 1
NM_001394887.1 NP_001381816.1 LIM domain and actin-binding protein 1 isoform 2
NM_001394888.1 NP_001381817.1 LIM domain and actin-binding protein 1 isoform 2
NM_001394889.1 NP_001381818.1 LIM domain and actin-binding protein 1 isoform 5
NM_001394890.1 NP_001381819.1 LIM domain and actin-binding protein 1 isoform 6
NM_001394891.1 NP_001381820.1 LIM domain and actin-binding protein 1 isoform 7
NM_001394892.1 NP_001381821.1 LIM domain and actin-binding protein 1 isoform 8
NM_001394893.1 NP_001381822.1 LIM domain and actin-binding protein 1 isoform 9
NM_016357.5 NP_057441.1 LIM domain and actin-binding protein 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin filament binding IDA
IDA: 通过直接分析推断
12566430 GOA
enables actin monomer binding IDA
IDA: 通过直接分析推断
12566430 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15161933 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin filament bundle assembly IDA
IDA: 通过直接分析推断
12566430 GOA
involved in negative regulation of actin filament depolymerization IDA
IDA: 通过直接分析推断
12566430 GOA
involved in ruffle organization IDA
IDA: 通过直接分析推断
12566430 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cleavage furrow IDA
IDA: 通过直接分析推断
20309963 GOA
located in focal adhesion IDA
IDA: 通过直接分析推断
10618726 GOA
located in stress fiber IDA
IDA: 通过直接分析推断
10618726 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LIMA1 蛋白结构

LIM

LIM: LIM domain (390 - 445)

  • 0
  • 200
  • 400
  • 600
  • 759 a.a.
蛋白主名 其他名称

LIM domain and actin-binding protein 1

epithelial protein lost in neoplasm beta

LIMA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LIMA1 Q9UHB6 YWHAZ Homo sapiens P63104
Pull Down
15161933
种属内
LIMA1 Q9UHB6 DAPK1 Homo sapiens P53355
Protein Array
29513927
种属内
LIMA1 Q9UHB6 CTNNA1 Homo sapiens P35221
Anti Bait CoIP
18093941
种属内
LIMA1 Q9UHB6 CDH1 Homo sapiens P12830
Anti Bait CoIP
18093941
种属间
LIMA1 Q9UHB6 SVIL Bos taurus O46385
Y2H
20309963
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Low Density Lipoprotein Cholesterol Level Quantitative Trait Locus 8

LDLCQ8

Low Density Lipoprotein Cholesterol Level Qtl 8
Retinitis Pigmentosa 54

RP54

Retinitis Pigmentosa, Type 54
Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome

Deletion 1p36

Monosomy 1p36

Subtelomeric 1p36 Deletion

Monosomy 1p36 Syndrome

Distal Monosomy 1p36

Del(1)(P36)

Deletion 1pter

Monosomy 1pter
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07657 LIMA1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LIMA1 RGD RGD:1564050
Bos taurus LIMA1 VGNC VGNC:30886
Mus musculus LIMA1 MGD MGI:1920992
Macaca mulatta LIMA1 VGNC VGNC:74114
Felis catus LIMA1 VGNC VGNC:63228
Canis familiaris LIMA1 VGNC VGNC:42677
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