2. Gene
  3. TRIAP1 - TP53 regulated inhibitor of apoptosis 1 Gene

TRIAP1 - TP53 regulated inhibitor of apoptosis 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TP53 调节细胞凋亡抑制因子 1

种属: Homo sapiens

同用名: WF-1; MDM35; P53CSV; HSPC132

基因 ID: 51499 | 基因类型: protein coding

关于 TRIAP1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,443,964-120,446,384 (from NCBI)

This gene has 2 transcripts (splice variants) and 101 orthologues. Ubiquitous expression in colon (RPKM 17.2), liver (RPKM 15.9) and 25 other tissues.

功能概要

启用 p53 绑定活动。有助于磷脂酸转移活性。参与多个过程，包括 DNA 损伤反应、p53 类介质的信号转导；细胞凋亡过程的负调控；和磷脂转运的积极调节。位于线粒体膜间隙和核质中。部分含蛋白质复合物。 [由基因组资源联盟提供，2022 年 4 月]

Enables p53 binding activity. Contributes to phosphatidic acid transfer activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of apoptotic process; and positive regulation of phospholipid transport. Located in mitochondrial intermembrane space and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

TRIAP1 基因产物(1)

mRNA Protein Name
NM_016399.3 NP_057483.1 TP53-regulated inhibitor of apoptosis 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables p53 binding IPI
IPI: 通过物理相互作用推断
15735003 GOA
contributes to phosphatidic acid transfer activity IDA
IDA: 通过直接分析推断
23931759 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15735003 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response, signal transduction by p53 class mediator IDA
IDA: 通过直接分析推断
15735003 GOA
involved in cellular response to UV IDA
IDA: 通过直接分析推断
15735003 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
23931759 GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
15735003 GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: 通过突变表型推断
15735003 GOA
involved in negative regulation of release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
23931759 GOA
involved in phospholipid transport IDA
IDA: 通过直接分析推断
26071602 GOA
involved in positive regulation of phospholipid transport IDA
IDA: 通过直接分析推断
23931759 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15735003 GOA
involved in regulation of membrane lipid distribution IMP
IMP: 通过突变表型推断
23931759 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial intermembrane space IDA
IDA: 通过直接分析推断
23931759 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
15735003 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
23931759 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIAP1 蛋白结构

UPF0203

UPF0203: Uncharacterised protein family (UPF0203) (1 - 70)

  • 0
  • 76 a.a.
蛋白主名 其他名称

TP53-regulated inhibitor of apoptosis 1

mitochondrial distribution and morphology 35 homolog

TRIAP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TRIAP1 O43715 LCN2 Homo sapiens P80188
Validated Y2H
32296183
种属内
TRIAP1 O43715 LCN2 Homo sapiens P80188
Y2H Array
32296183
种属内
TRIAP1 O43715 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
种属内
TRIAP1 O43715 PRELID3B Homo sapiens Q9Y3B1
Anti Tag CoIP
33961781
种属内
TRIAP1 O43715 PRELID3B Homo sapiens Q9Y3B1
Anti Tag CoIP
28514442
种属内
TRIAP1 O43715 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
种属内
TRIAP1 O43715 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
种属内
TRIAP1 O43715 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Penile Cancer

Penis Carcinoma

Carcinoma Of Penis

Penile Neoplasm

Penile Carcinoma

Penile Neoplasms

Malignant Neoplasm Of Penis

Ca Penis

Malignant Neoplasm Of Body Of Penis

Malignant Penile Tumor

Penile Ca
Immune-Complex Glomerulonephritis

Immune Complex Glomerulonephritis
Waardenburg Syndrome, Type 1

Waardenburg Syndrome Type 1

WS1

Waardenburg Syndrome Type I

Waardenburg Syndrome With Dystopia Canthorum

Waardenburg'S Syndrome Type 1

Waardenburg Syndrome 1

Waardenburg Syndrome, Type I

Waardenburg Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15014 TRIAP1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TRIAP1 VGNC VGNC:36307
Canis familiaris TRIAP1 VGNC VGNC:47800
Rattus norvegicus TRIAP1 RGD RGD:1586233
Mus musculus TRIAP1 MGD MGI:1916326
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