2. Gene
  3. Ppp2r1a - protein phosphatase 2, regulatory subunit A, alpha Gene

Ppp2r1a - protein phosphatase 2, regulatory subunit A, alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PP2A; PR65; 6330556D22Rik

基因 ID: 51792 | 基因类型: protein coding

关于 Ppp2r1a

功能概要

Enables protein serine/threonine Phosphatase activity. Acts upstream of or within several processes, including nuclear division; peptidyl-serine dephosphorylation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytosol and glutamatergic synapse. Part of protein Phosphatase type 2A complex. Is active in synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 36. Orthologous to human PPP2R1A (protein Phosphatase 2 scaffold subunit Aalpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppp2r1a 基因产物(1)

mRNA Protein Name
NM_016891.3 NP_058587.1 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12885400 MGI
enables protein serine/threonine phosphatase activity IDA
IDA: 通过直接分析推断
12944463 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell homeostasis IMP
IMP: 通过突变表型推断
26974206 MGI
acts upstream of or within female meiotic nuclear division IMP
IMP: 通过突变表型推断
24899574 MGI
acts upstream of or within meiotic sister chromatid cohesion, centromeric IMP
IMP: 通过突变表型推断
24899574 MGI
acts upstream of or within meiotic spindle elongation IMP
IMP: 通过突变表型推断
24899574 MGI
acts upstream of or within mitotic sister chromatid separation IMP
IMP: 通过突变表型推断
24899574 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
26974206 MGI
acts upstream of or within peptidyl-serine dephosphorylation IDA
IDA: 通过直接分析推断
12944463 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: 通过突变表型推断
12944463 MGI
acts upstream of or within regulation of meiotic cell cycle process involved in oocyte maturation IMP
IMP: 通过突变表型推断
24899574 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
12885400 MGI
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
24413018 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
24413018 MGI
part of protein phosphatase type 2A complex IDA
IDA: 通过直接分析推断
16717086 MGI
is active in synapse EXP
EXP: 通过实验结果推断
16452087 MGI
is active in synapse IDA
IDA: 通过直接分析推断
16452087 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

protein phosphatase PP2A

serine/threonine protein phosphatase A subunit type 2A

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11009 PPP2R1A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18724 Ppp2r1a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25211 Ppp2r1a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ppp2r1a NCBI NCBI:5518
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