2. Gene
  3. PCBP3 - poly(rC) binding protein 3 Gene

PCBP3 - poly(rC) binding protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：聚 (rC) 结合蛋白 3

种属: Homo sapiens

同用名: PCBP3OT; ALPHA-CP3; PCBP3-OT1

基因 ID: 54039 | 基因类型: protein coding

关于 PCBP3

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:45,643,725-45,942,450 (from NCBI)

This gene has 22 transcripts (splice variants), 164 orthologues and 12 paralogues. Broad expression in testis (RPKM 8.3), endometrium (RPKM 4.4) and 17 other tissues.

功能概要

该基因编码 KH 结构域蛋白亚家族的一个成员。该亚家族的蛋白质，也称为 alpha-CP，与 RNA 结合，对富含 C 的嘧啶区域具有特异性。 Alpha-CP 在转录后活动中发挥重要作用，并具有不同的细胞分布。由该基因编码的蛋白质缺乏在其他亚家族成员中发现的核定位信号。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2017 年 1 月]

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in Other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]

PCBP3 基因产物(23)

mRNA Protein Name
NM_001130141.2 NP_001123613.1 poly(rC)-binding protein 3 isoform 2
NM_001348238.2 NP_001335167.1 poly(rC)-binding protein 3 isoform 3
NM_001348239.2 NP_001335168.1 poly(rC)-binding protein 3 isoform 4
NM_001348240.2 NP_001335169.1 poly(rC)-binding protein 3 isoform 5
NM_001348241.2 NP_001335170.1 poly(rC)-binding protein 3 isoform 6
NM_001348242.2 NP_001335171.1 poly(rC)-binding protein 3 isoform 7
NM_001348243.2 NP_001335172.1 poly(rC)-binding protein 3 isoform 8
NM_001348244.2 NP_001335173.1 poly(rC)-binding protein 3 isoform 9
NM_001348245.2 NP_001335174.1 poly(rC)-binding protein 3 isoform 10
NM_001382276.1 NP_001369205.1 poly(rC)-binding protein 3 isoform 7
NM_001382277.1 NP_001369206.1 poly(rC)-binding protein 3 isoform 1
NM_001382278.1 NP_001369207.1 poly(rC)-binding protein 3 isoform 3
NM_001382279.1 NP_001369208.1 poly(rC)-binding protein 3 isoform 5
NM_001382281.1 NP_001369210.1 poly(rC)-binding protein 3 isoform 1
NM_001382282.1 NP_001369211.1 poly(rC)-binding protein 3 isoform 1
NM_001382283.1 NP_001369212.1 poly(rC)-binding protein 3 isoform 1
NM_001382284.1 NP_001369213.1 poly(rC)-binding protein 3 isoform 1
NM_001382285.1 NP_001369214.1 poly(rC)-binding protein 3 isoform 1
NM_001382286.1 NP_001369215.1 poly(rC)-binding protein 3 isoform 1
NM_001382287.1 NP_001369216.1 poly(rC)-binding protein 3 isoform 1
NM_001382288.1 NP_001369217.1 poly(rC)-binding protein 3 isoform 1
NM_001384156.1 NP_001371085.1 poly(rC)-binding protein 3 isoform 1
NM_020528.3 NP_065389.2 poly(rC)-binding protein 3 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PCBP3 蛋白结构

KH_1

KH_1: KH domain (47 - 107)

KH_1

KH_1: KH domain (131 - 194)

KH_1

KH_1: KH domain (296 - 357)

  • 0
  • 100
  • 200
  • 300
  • 371 a.a.
蛋白主名 其他名称

poly(rC)-binding protein 3

PCBP3 overlapping transcript 1

关联疾病

疾病名称 别名
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10117 PCBP3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18676 Pcbp3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25162 Pcbp3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PCBP3 RGD RGD:1307430
Bos taurus PCBP3 VGNC VGNC:53597
Canis familiaris PCBP3 VGNC VGNC:53035
Macaca mulatta PCBP3 VGNC VGNC:81735
Felis catus PCBP3 VGNC VGNC:102800
Mus musculus PCBP3 MGD MGI:1890470
Macaca fascicularis PCBP3 NCBI NCBI:101925063
Others PCBP3 NCBI
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