2. Gene
  3. Slc4a4 - solute carrier family 4 (anion exchanger), member 4 Gene

Slc4a4 - solute carrier family 4 (anion exchanger), member 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: NBC; NBC1

基因 ID: 54403 | 基因类型: protein coding

关于 Slc4a4

功能概要

Predicted to enable identical protein binding activity and sodium:bicarbonate symporter activity. Involved in regulation of intracellular pH. Acts upstream of or within bicarbonate transport and sodium ion transport. Predicted to be located in cell surface and membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including brain; metanephros; spinal cord floor plate; and thyroid primordium. Used to study renal tubular acidosis. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a4 基因产物(6)

mRNA Protein Name
NM_001136260.1 NP_001129732.1 electrogenic sodium bicarbonate cotransporter 1 isoform b
NM_001197147.1 NP_001184076.1 electrogenic sodium bicarbonate cotransporter 1 isoform c
NM_001359211.1 NP_001346140.1 electrogenic sodium bicarbonate cotransporter 1 isoform d
NM_001359212.1 NP_001346141.1 electrogenic sodium bicarbonate cotransporter 1 isoform e
NM_001359213.1 NP_001346142.1 electrogenic sodium bicarbonate cotransporter 1 isoform f
NM_018760.2 NP_061230.2 electrogenic sodium bicarbonate cotransporter 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14567693 MGI
enables sodium:bicarbonate symporter activity IDA
IDA: 通过直接分析推断
11171615 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within bicarbonate transport IGI
IGI: 通过遗传相互作用推断
19033647 MGI
acts upstream of or within establishment of localization in cell IGI
IGI: 通过遗传相互作用推断
19033647 MGI
acts upstream of positive regulation of glycolytic process IMP
IMP: 通过突变表型推断
21976511 MGI
acts upstream of regulation of intracellular pH IMP
IMP: 通过突变表型推断
21976511 MGI
involved in regulation of intracellular pH IMP
IMP: 通过突变表型推断
24453308 MGI
acts upstream of regulation of membrane potential IMP
IMP: 通过突变表型推断
21976511 MGI
acts upstream of or within sodium ion transport IDA
IDA: 通过直接分析推断
9651366 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
11171615 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

electrogenic sodium bicarbonate cotransporter 1

Na(+)/HCO3(-) cotransporter

pancreas sodium bicarbonate cotransporter

sodium bicarbonate cotransporter

solute carrier family 4 member 4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

Slc4a4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Slc4a4 O88343 Ca4 Mus musculus Q64444
Anti Bait CoIP
14567693
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13270 SLC4A4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19074 Slc4a4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25564 Slc4a4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc4a4 NCBI NCBI:8671
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