CROT - carnitine O-octanoyltransferase Gene

中文名称：肉碱 O-辛酰基转移酶

种属: Homo sapiens

同用名: COT

关于 CROT

功能概要

该基因编码肉毒碱/胆碱乙酰转移酶家族的成员。编码的蛋白质将 4,8-二甲基壬酰辅酶 A 转化为其相应的肉碱酯。这种酯交换发生在过氧化物酶体中，并且是将中链和长链酰基辅酶 A 分子从过氧化物酶体转运到胞质溶胶和线粒体所必需的。因此，该蛋白质在脂质代谢和脂肪酸 β-氧化中发挥作用。已经描述了选择性剪接的转录变体。[RefSeq 提供，2009 年 1 月]

This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]