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  2. PPEF2 - protein phosphatase with EF-hand domain 2 Gene

PPEF2 - protein phosphatase with EF-hand domain 2 Gene

中文名称:具有 EF 手域 2 的蛋白磷酸酶

种属: Homo sapiens

同用名: PPP7CB

基因 ID: 5470 | 基因类型: protein coding

关于 PPEF2

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,859,867-75,902,452 (from NCBI)

This gene has 8 transcripts (splice variants), 289 orthologues and 12 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码具有 EF 手基序家族的丝氨酸/苏氨酸蛋白磷酸酶成员。该蛋白质包含一个蛋白磷酸酶催化结构域,并且在其 C 末端至少包含两个 EF 手钙结合基序。尽管其底物未知,但已表明在光感受器和松果体中特异性表达的编码蛋白质在视觉系统中发挥作用。该基因与果蝇视网膜变性 C (rdgC) 基因具有高度序列相似性。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the serine/threonine protein Phosphatase with EF-hand motif family. The protein contains a protein Phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein, which is expressed specifically in photoreceptors and the pineal, has been suggested to play a role in the visual system. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. [provided by RefSeq, Jul 2008]

PPEF2 基因产物(1)

mRNA Protein Name
NM_006239.3 NP_006230.2 serine/threonine-protein phosphatase with EF-hands 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Hsp70 protein binding IDA
IDA: 通过直接分析推断
20674765 GOA
enables Hsp90 protein binding IDA
IDA: 通过直接分析推断
20674765 GOA
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: 通过物理相互作用推断
20674765 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12051765 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of MAPK cascade IDA
IDA: 通过直接分析推断
20674765 GOA
involved in negative regulation of peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
20674765 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PPEF2 蛋白结构

PPP5

PPP5: PPP5 TPR repeat region (95 - 163)

Metallophos

Metallophos: Calcineurin-like phosphoesterase (174 - 492)

EF-hand_7

EF-hand_7: EF-hand domain pair (657 - 721)

  • 0
  • 200
  • 400
  • 600
  • 753 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase with EF-hands 2

protein phosphatase 7, catalytic subunit, beta isozyme

关联疾病

疾病名称 别名
Retinal Degeneration

Degeneration Of Retina

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PPEF2 MGD MGI:1342304
Felis catus PPEF2 VGNC VGNC:68982
Bos taurus PPEF2 VGNC VGNC:53771
Macaca mulatta PPEF2 VGNC VGNC:76233
Canis familiaris PPEF2 VGNC VGNC:57408
Rattus norvegicus PPEF2 RGD RGD:1307093