2. Gene
  3. HPF1 - histone PARylation factor 1 Gene

HPF1 - histone PARylation factor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：组蛋白 PARylation 因子 1

种属: Homo sapiens

同用名: C4orf27

基因 ID: 54969 | 基因类型: protein coding

关于 HPF1

Cytogenetic location: 4q33 Genomic coordinates (GRCh38): 4:169,729,470-169,757,944 (from NCBI)

This gene has 3 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in brain (RPKM 6.3), endometrium (RPKM 6.0) and 25 other tissues.

功能概要

启用染色质结合活性和组蛋白结合活性。参与双链断裂修复；肽基-丝氨酸 ADP-核糖基化；蛋白质修饰过程的调控。位于染色质；核;和 DNA 损伤部位。 [由基因组资源联盟提供，2022 年 4 月]

Enables chromatin binding activity and histone binding activity. Involved in double-strand break repair; peptidyl-serine ADP-ribosylation; and regulation of protein modification process. Located in chromatin; nucleus; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]

HPF1 基因产物(1)

mRNA Protein Name
NM_017867.3 NP_060337.2 histone PARylation factor 1

HPF1 蛋白结构

DUF2228

DUF2228: Uncharacterised conserved protein (DUF2228) (77 - 328)

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  • 346 a.a.
蛋白主名 其他名称

histone PARylation factor 1

UPF0609 protein C4orf27

关联疾病

疾病名称 别名
Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures

CONDSIAS

Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06337 HPF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HPF1 MGD MGI:1919862
Bos taurus HPF1 VGNC VGNC:56972
Macaca mulatta HPF1 VGNC VGNC:100235
Rattus norvegicus HPF1 RGD RGD:1311747
Canis familiaris HPF1 VGNC VGNC:50635
Felis catus HPF1 VGNC VGNC:78510
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