PI4K2A - phosphatidylinositol 4-kinase type 2 alpha Gene

中文名称：磷脂酰肌醇 4-激酶 2 型α

种属: Homo sapiens

同用名: PI4KII; PIK42A

基因 ID: 55361 | 基因类型: protein coding

关于 PI4K2A

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:97,640,671-97,676,434 (from NCBI)

This gene has 1 transcript (splice variant), 224 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 11.9), gall bladder (RPKM 10.1) and 25 other tissues.

功能概要

磷脂酰肌醇多磷酸盐 (PtdInsPs) 主要参与许多生物过程，从细胞生长和肌动蛋白细胞骨架的组织到胞吐作用和胞吐作用。 PI4KII 在 D-4 位置磷酸化 PtdIns，这是 PtdInsPs 生物合成的重要步骤 (Barylko 等人，2001 [PubMed 11244087]) 。[OMIM 提供，2008 年 3 月]

Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin Cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]

PI4K2A 基因产物(1)

mRNA	Protein	Name
NM_018425.4	NP_060895.1	phosphatidylinositol 4-kinase type 2-alpha

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 1-phosphatidylinositol 4-kinase activity	IDA IDA: 通过直接分析推断	11279162	GOA
enables AP-3 adaptor complex binding	IDA IDA: 通过直接分析推断	21998198	GOA
enables ATP binding	IDA IDA: 通过直接分析推断	24675427	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21998198	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in phosphatidylinositol biosynthetic process	IDA IDA: 通过直接分析推断	11279162	GOA
involved in phosphatidylinositol phosphate biosynthetic process	IDA IDA: 通过直接分析推断	11923287	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of BLOC-1 complex	IDA IDA: 通过直接分析推断	21998198	GOA
located in Golgi membrane	IDA IDA: 通过直接分析推断	12324459	GOA
located in early endosome membrane	IDA IDA: 通过直接分析推断	11923287	GOA
located in endosome membrane	IDA IDA: 通过直接分析推断	35880319	GOA
located in membrane	IDA IDA: 通过直接分析推断	24675427	GOA
located in membrane raft	IDA IDA: 通过直接分析推断	11279162	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	11279162	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PI4K2A 蛋白结构

PI3_PI4_kinase

0
100
200
300
400
479 a.a.

蛋白主名

其他名称

phosphatidylinositol 4-kinase type 2-alpha

phosphatidylinositol 4-kinase type II (PI4KII)

PI4K2A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PI4K2A	Q9BTU6	ITCH	Homo sapiens	Q96J02	Pull Down	23146885
种属内	PI4K2A	Q9BTU6	ITCH	Homo sapiens	Q96J02	NMR	23146885

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cutis Laxa, Autosomal Recessive, Type Iid

ARCL2D	Autosomal Recessive Cutis Laxa Type Iid
Autosomal Recessive Cutis Laxa Type 2d	Cutis Laxa, Autosomal Recessive, 2d

Cutis Laxa, Autosomal Dominant 3

ADCL3	Autosomal Dominant Cutis Laxa 3
Cutis Laxa, Autosomal Dominant, 3

Congenital Aphakia

Congenital Absence Of Lens	Aphakia, Congenital Primary
Agenesis Of Lens

Lenz-Majewski Hyperostotic Dwarfism

Lenz-Majewski Syndrome	Lenz Majewski Hyperostotic Dwarfism
LMHD	Hyperostotic Dwarfism Lenz-Majewski Type
Lenz-Majewski Hyperostotic Dysplasia	Multiple Congenital Anomalies, Intellectual Disability And Progressive Skeletal Sclerosis
Lms

Spastic Paraplegia 15, Autosomal Recessive

SPG15	Kjellin Syndrome
Hereditary Spastic Paraplegia 15	Spastic Paraplegia And Retinal Degeneration
Autosomal Recessive Spastic Paraplegia Type 15	Hereditary Spastic Paraparesis Type 15
Spastic Paraplegia-Retinal Degeneration Syndrome	Autosomal Recessive Spastic Paraplegia 15

Macrocephaly/Autism Syndrome

Macrocephaly-Autism Syndrome	Macrocephaly-Intellectual Disability-Autism Syndrome
MCEPHAS

Autosomal Recessive Cutis Laxa Type Ii Classic Type

Arcl2, Classic Type	Arcl2, Debre Type
Autosomal Recessive Cutis Laxa Type 2, Classic Type	Autosomal Recessive Cutis Laxa Type 2, Debre Type

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-115675	NC03	Inhibitor	98.79%	否
HY-RS10464	PI4K2A Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS20578	Pi4k2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27086	Pi4k2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	PI4K2A	VGNC	VGNC:110529
Felis catus	PI4K2A	VGNC	VGNC:110546
Mus musculus	PI4K2A	MGD	MGI:1934031
Bos taurus	PI4K2A	VGNC	VGNC:107302
Rattus norvegicus	PI4K2A	RGD	RGD:620485
Others	PI4K2A	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PI4K2A - phosphatidylinositol 4-kinase type 2 alpha Gene

关于 PI4K2A

功能概要

PI4K2A 基因产物(1)

PI4K2A 蛋白结构

PI4K2A 蛋白互作信息

关联疾病

直系同源

热门区域

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PI4K2A - phosphatidylinositol 4-kinase type 2 alpha Gene

关于 PI4K2A

功能概要

PI4K2A 基因产物(1)

PI4K2A 蛋白结构

PI4K2A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z