PRIM2 - DNA primase subunit 2 Gene

中文名称：DNA 引物酶亚基 2

种属: Homo sapiens

同用名: p58; PRIM2A

关于 PRIM2

功能概要

该基因编码 DNA 引物酶的 58 道尔顿亚基，该酶在 DNA 复制中起着关键作用。编码的蛋白质形成具有 49 道尔顿亚基的异二聚体。这种异二聚体用作 DNA 指导的 RNA 聚合酶，以合成用于在 DNA 滞后链上产生冈崎片段的小 RNA 引物。该基因的可变剪接导致多个转录变体。该基因有一个相关的假基因，它也存在于 6 号染色体上。[RefSeq 提供，2014 年 4 月]

This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014]