1. Gene
  2. CENPN - centromere protein N Gene

CENPN - centromere protein N Gene

中文名称:着丝粒蛋白 N

种属: Homo sapiens

同用名: BM039; CENP-N; ICEN32; C16orf60

基因 ID: 55839 | 基因类型: protein coding

关于 CENPN

Cytogenetic location: 16q23.2 Genomic coordinates (GRCh38): 16:81,007,214-81,033,107 (from NCBI)

This gene has 9 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in prostate (RPKM 4.4), bone marrow (RPKM 3.9) and 25 other tissues.

功能概要

由该基因编码的蛋白质构成核小体相关复合物的一部分,对着丝粒组装很重要。它在 S 期和 G2 期与着丝粒结合,并将其他蛋白质募集到着丝粒。该基因的假基因位于 2 号染色体上。可变剪接导致编码不同蛋白质亚型的多个转录变体。[RefSeq 提供,2012 年 7 月]

The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits Other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

CENPN 基因产物(5)

mRNA Protein Name
NM_001100624.3 NP_001094094.2 centromere protein N isoform 2
NM_001100625.3 NP_001094095.2 centromere protein N isoform 1
NM_001270473.2 NP_001257402.1 centromere protein N isoform 4
NM_001270474.2 NP_001257403.1 centromere protein N isoform 5
NM_018455.6 NP_060925.2 centromere protein N isoform 3
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of inner kinetochore IPI
IPI: 通过物理相互作用推断
36085283 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CENPN 蛋白结构

CENP-N

CENP-N: Kinetochore protein CHL4 like (5 - 339)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
蛋白主名 其他名称

centromere protein N

interphase centromere complex protein 32

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CENPN VGNC VGNC:71146
Mus musculus CENPN MGD MGI:1919405
Bos taurus CENPN VGNC VGNC:27182
Canis familiaris CENPN VGNC VGNC:39109
Rattus norvegicus CENPN RGD RGD:1310953