1. Gene
  2. ARHGAP15 - Rho GTPase activating protein 15 Gene

ARHGAP15 - Rho GTPase activating protein 15 Gene

中文名称:Rho GTP 酶激活蛋白 15

种属: Homo sapiens

同用名: BM046

基因 ID: 55843 | 基因类型: protein coding

关于 ARHGAP15

Cytogenetic location: 2q22.2-q22.3 Genomic coordinates (GRCh38): 2:143,129,419-143,768,352 (from NCBI)

This gene has 13 transcripts (splice variants), 201 orthologues and 3 paralogues. Broad expression in lymph node (RPKM 10.3), bone marrow (RPKM 9.8) and 18 other tissues.

功能概要

RHO GTPases (参见 ARHA;MIM 165390) 调节多种生物过程,它们的活性受 RHO GTPase 激活蛋白 (GAP) 调节,例如 ARHGAP15 (Seoh 等人,2003 [PubMed 12650940]) 。[OMIM 提供, 2008 年 3 月]

RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]

ARHGAP15 基因产物(1)

mRNA Protein Name
NM_018460.4 NP_060930.3 rho GTPase-activating protein 15
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IDA
IDA: 通过直接分析推断
12650940 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within regulation of cell shape IDA
IDA: 通过直接分析推断
12650940 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ARHGAP15 蛋白结构

PH

PH: PH domain (80 - 188)

RhoGAP

RhoGAP: RhoGAP domain (295 - 444)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 475 a.a.
蛋白主名 其他名称

rho GTPase-activating protein 15

rho-type GTPase-activating protein 15

ARHGAP15 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ARHGAP15 Q53QZ3 DHPS Homo sapiens P49366 33961781
种属内
ARHGAP15 Q53QZ3 DHPS Homo sapiens P49366 28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Diverticulitis
Mowat-Wilson Syndrome

MOWS

Microcephaly, Mental Retardation, And Distinct Facial Features, With Or Without Hirschsprung Disease

Hirschsprung Disease-Mental Retardation Syndrome

Mowat-Wilson Syndrome Due To Monosomy 2q22

Hirschsprung Disease Mental Retardation Syndrome

Microcephaly, Mental Retardation, And Distinct Facial Featrues, With Or Without Hirschprung Disease

Hirschsprung Disease - Intellectual Disability Syndrome

Hirschsprung Disease Intellectual Disability Syndrome

Intellectual Disability, Microcephaly, And Distinct Facial Features With Or Without Hirschsprung Disease

Mws

Hirschsprung Disease-Intellectual Disability Syndrome

Hirschsprung Disease And Intellectual Disability Due To 2q22 Microdeletion

Hirschsprung Disease And Intellectual Disability Due To Del(2)(Q22)

Hirschsprung Disease And Intellectual Disability Due To Monosomy 2q22

Mowat-Wilson Syndrome Due To 2q22 Microdeletion

Mowat-Wilson Syndrome Due To Del(2)Q(22)

Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation

Hirschsprung Disease And Intellectual Disability Due To A Zeb2 Point Mutation

Meier-Gorlin Syndrome 2

MGORS2

Meier-Gorlin Syndrome, Type 2

Epilepsy, Idiopathic Generalized 9

Epilepsy, Idiopathic Generalized, Susceptibility To, 9

EIG9

Epilepsy, Juvenile Myoclonic 6

Idiopathic Generalized Epilepsy 9

Epilepsy, Juvenile Myoclonic, Susceptibility To, 6

Susceptibility To Idiopathic Generalized Epilepsy 9

Juvenile Myoclonic Epilepsy 6

EJM6

Susceptibility To Juvenile Myoclonic Epilepsy 6

Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 9

Diverticulitis Of Colon

Colonic Diverticular Disease

Diverticulitis, Colonic

Diverticular Disease Of Colon

Bladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Bladder

Epidermoid Carcinoma Of The Urinary Bladder

Carcinoma Squamous Cell Bladder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ARHGAP15 MGD MGI:1923367
Felis catus ARHGAP15 VGNC VGNC:59876
Bos taurus ARHGAP15 VGNC VGNC:26076
Rattus norvegicus ARHGAP15 RGD RGD:1359304
Canis familiaris ARHGAP15 VGNC VGNC:38047
Macaca mulatta ARHGAP15 VGNC VGNC:69874