2. Gene
  3. PRKG2 - protein kinase cGMP-dependent 2 Gene

PRKG2 - protein kinase cGMP-dependent 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 cGMP 依赖性 2

种属: Homo sapiens

同用名: AMD4; PKG2; SMDP; cGK2; cGKII; PRKGR2

基因 ID: 5593 | 基因类型: protein coding

关于 PRKG2

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:81,087,370-81,217,836 (from NCBI)

This gene has 7 transcripts (splice variants), 185 orthologues, 5 paralogues and is associated with 3 phenotypes. Biased expression in prostate (RPKM 4.2), small intestine (RPKM 4.1) and 11 other tissues.

功能概要

该基因编码一种属于丝氨酸/苏氨酸蛋白激酶家族的蛋白质。编码的蛋白质结合并抑制几种受体酪氨酸激酶的激活。膜结合蛋白是肠分泌、骨骼生长和肾素分泌的调节剂。交替剪接导致编码不同异构体的多个转录变体，其调节 N 末端的长度不同，但其 C 末端催化结构域相同。[RefSeq 提供，2018 年 5 月]

This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several Receptor Tyrosine Kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and Renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018]

PRKG2 基因产物(7)

mRNA Protein Name
NM_001282480.1 NP_001269409.1 cGMP-dependent protein kinase 2 isoform b
NM_001282481.1 NP_001269410.1 cGMP-dependent protein kinase 2 isoform b
NM_001282482.1 NP_001269411.1 cGMP-dependent protein kinase 2 isoform c
NM_001282483.1 NP_001269412.1 cGMP-dependent protein kinase 2 isoform d
NM_001282485.2 NP_001269414.1 cGMP-dependent protein kinase 2 isoform e
NM_001363401.2 NP_001350330.1 cGMP-dependent protein kinase 2 isoform a
NM_006259.3 NP_006250.1 cGMP-dependent protein kinase 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cGMP-dependent protein kinase activity IMP
IMP: 通过突变表型推断
33106379 GOA
enables mitogen-activated protein kinase binding IMP
IMP: 通过突变表型推断
33106379 GOA
enables protein serine kinase activity IMP
IMP: 通过突变表型推断
33106379 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
15905169 GOA
involved in signal transduction IMP
IMP: 通过突变表型推断
33106379 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKG2 蛋白结构

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (187 - 269)

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (305 - 393)

Pkinase

Pkinase: Protein kinase domain (454 - 711)

  • 0
  • 200
  • 400
  • 600
  • 762 a.a.
蛋白主名 其他名称

cGMP-dependent protein kinase 2

cGMP-dependent protein kinase II

关联疾病

疾病名称 别名
Spondylometaphyseal Dysplasia, Pagnamenta Type

SMDP

Dysplasia, Spondylometaphyseal, Pagnamenta Type
Acromesomelic Dysplasia 4

AMD4

Acromesomelic Dysplasia-4

Dysplasia, Acromesomelic, Type 4
Acromesomelic Dysplasia

Acromesomelic Dwarfism

Dysplasia, Acromesomelic

Acromesomelic Dysplasia Hunter-Thompson Type
Chromosome 4q21 Deletion Syndrome

4q21 Microdeletion Syndrome

Monosomy 4q21

Del(4)(Q21)

Chromosome Deletion Syndrome 4q21
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Hyperphenylalaninemia

Hyperphenylalaninaemia
Brachydactyly
Malignant Hemangioma
Secretory Diarrhea
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Osteochondrodysplasia

Skeletal Dysplasia

Chondrodystrophy

Congenital Anomaly Of Cartilage

Osteochondrodysplasias

Cartilage Development Disorder

Osteochondrodysplasia Syndrome

Dysplasia, Skeletal

Mucopolysaccharidosis Iv
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11155 PRKG2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PRKG2 VGNC VGNC:44990
Mus musculus PRKG2 MGD MGI:108173
Macaca mulatta PRKG2 VGNC VGNC:76420
Bos taurus PRKG2 VGNC VGNC:33341
Rattus norvegicus PRKG2 RGD RGD:3401
Felis catus PRKG2 VGNC VGNC:69070
Others PRKG2 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z