2. Gene
  3. MAPK4 - mitogen-activated protein kinase 4 Gene

MAPK4 - mitogen-activated protein kinase 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶 4

种属: Homo sapiens

同用名: ERK4; ERK-4; PRKM4; p63MAPK; p63-MAPK

基因 ID: 5596 | 基因类型: protein coding

关于 MAPK4

Cytogenetic location: 18q21.1-q21.2 Genomic coordinates (GRCh38): 18:50,559,612-50,731,826 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 207 orthologues and 19 paralogues. Biased expression in adrenal (RPKM 3.2), brain (RPKM 3.1) and 11 other tissues.

功能概要

丝裂原活化蛋白激酶 4 是丝裂原活化蛋白激酶家族的成员。酪氨酸激酶生长因子受体激活丝裂原活化蛋白激酶，然后转移到细胞核中并磷酸化核靶标。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 5 月]

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

MAPK4 基因产物(3)

mRNA Protein Name
NM_001292039.2 NP_001278968.1 mitogen-activated protein kinase 4 isoform 2
NM_001292040.2 NP_001278969.1 mitogen-activated protein kinase 4 isoform 3
NM_002747.4 NP_002738.2 mitogen-activated protein kinase 4 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22939624 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAPK4 蛋白结构

Pkinase

Pkinase: Protein kinase domain (23 - 312)

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  • 587 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase 4

Erk3-related

MAPK4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAPK4 P31152 HSP90AB1 Homo sapiens P08238
Lumier
22939624
种属内
MAPK4 P31152 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-172781 HDAC6-IN-55 Inhibitor / 否
HY-RS08116 MAPK4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17984 Mapk4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19216 Mapk6 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24455 Mapk4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MAPK4 RGD RGD:3047
Canis familiaris MAPK4 VGNC VGNC:42998
Mus musculus MAPK4 MGD MGI:2444559
Bos taurus MAPK4 VGNC VGNC:31220
Macaca mulatta MAPK4 VGNC VGNC:74647
Felis catus MAPK4 VGNC VGNC:68169
Others MAPK4 NCBI
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