MAP2K3 - mitogen-activated protein kinase kinase 3 Gene

中文名称：丝裂原活化蛋白激酶激酶 3

种属: Homo sapiens

同用名: MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2

基因 ID: 5606 | 基因类型: protein coding

关于 MAP2K3

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:21,284,711-21,315,240 (from NCBI)

This gene has 15 transcripts (splice variants), 133 orthologues and 35 paralogues. Ubiquitous expression in bone marrow (RPKM 62.9), gall bladder (RPKM 18.4) and 23 other tissues.

功能概要

该基因编码的蛋白质是一种双特异性蛋白激酶，属于 MAP 激酶激酶家族。该激酶被促有丝分裂和环境压力激活，并参与 MAP 激酶介导的信号级联。它磷酸化并因此激活 MAPK14/p38-MAPK。这种激酶可以被胰岛素激活，是葡萄糖转运蛋白表达所必需的。发现 Ras 致癌基因的表达导致该激酶活性形式的积累，从而导致 MAPK14 的组成型激活，并赋予原代细胞致癌转化。这种激酶的抑制与耶尔森氏菌假结核病的发病机制有关。已经报道了该基因编码不同亚型的多个选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by Insulin, and is necessary for the expression of glucose transporter. Expression of Ras oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

MAP2K3 基因产物(3)

mRNA	Protein	Name
NM_001316332.2	NP_001303261.1	dual specificity mitogen-activated protein kinase kinase 3 isoform A
NM_002756.4	NP_002747.2	dual specificity mitogen-activated protein kinase kinase 3 isoform A
NM_145109.3	NP_659731.1	dual specificity mitogen-activated protein kinase kinase 3 isoform B

MAP2K3 蛋白结构

Pkinase

0
100
200
300
347 a.a.

蛋白主名

其他名称

dual specificity mitogen-activated protein kinase kinase 3

MAP kinase kinase 3

关联疾病

疾病名称

别名

Inhalation Anthrax

Pulmonary Anthrax	Respiratory Anthrax
Inhalational Anthrax	Wool-Sorters' Disease
Woolsorters' Disease	Inhalation Anthrax Disease
Respiratory Anthrax Disease

Cutaneous Anthrax

Anthrax, Skin Type

Skin Anthrax

Pulmonary Systemic Sclerosis

Lung Disease With Systemic Sclerosis

Lung Involvement In Systemic Sclerosis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Cardiomyopathy, Familial Hypertrophic, 25

Hypertrophic Cardiomyopathy 25	CMH25
Cardiomyopathy, Hypertrophic, 25	Cardiomyopathy Familial Hypertrophic 25
Cardiomyopathy, Familial Hypertrophic 25	Cardiomyopathy, Hypertrophic, Type 25

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08039	MAP2K3 Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	MAP2K3	VGNC	VGNC:97491
Macaca mulatta	MAP2K3	VGNC	VGNC:81454
Mus musculus	MAP2K3	MGD	MGI:1346868
Canis familiaris	MAP2K3	VGNC	VGNC:42961
Rattus norvegicus	MAP2K3	RGD	RGD:1306620
Bos taurus	MAP2K3	VGNC	VGNC:31184

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)	站点地图隐私声明
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.	沪ICP备15051369号-4

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

MAP2K3 - mitogen-activated protein kinase kinase 3 Gene

关于 MAP2K3

功能概要

MAP2K3 基因产物(3)

MAP2K3 蛋白结构

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

MAP2K3 - mitogen-activated protein kinase kinase 3 Gene

关于 MAP2K3

功能概要

MAP2K3 基因产物(3)

MAP2K3 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z