2. Gene
  3. Tgm2 - transglutaminase 2 Gene

Tgm2 - transglutaminase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: tTG; TgaseII

基因 ID: 56083 | 基因类型: protein coding

关于 Tgm2

功能概要

Enables GTP binding activity; identical protein binding activity; and protein domain specific binding activity. Involved in several processes, including isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of cytosolic calcium ion concentration involved in Phospholipase C-activating G protein-coupled signaling pathway. Acts upstream of or within Phospholipase C-activating G protein-coupled receptor signaling pathway. Located in several cellular components, including cytosol; mitochondrion; and nucleus. Orthologous to human TGM2 (Transglutaminase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tgm2 基因产物(1)

mRNA Protein Name
NM_019386.3 NP_062259.3 protein-glutamine gamma-glutamyltransferase 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTP binding IDA
IDA: 通过直接分析推断
14970202 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
12469910 RGD
enables phospholipase binding IPI
IPI: 通过物理相互作用推断
16709602 RGD
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
12054611 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in blood vessel remodeling IMP
IMP: 通过突变表型推断
15550691 RGD
involved in isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine IDA
IDA: 通过直接分析推断
16341586 RGD
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
7911253 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
11073883 RGD
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
15471861 RGD
involved in positive regulation of smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
14970202 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
7911253 RGD
located in cytosol IDA
IDA: 通过直接分析推断
11073883 RGD
located in nucleus IDA
IDA: 通过直接分析推断
11073883 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein-glutamine gamma-glutamyltransferase 2

TGase 2

TGase II

glutamine gamma-glutamyltransferase 2

isopeptidase TGM2

protein G alpha(h)

protein G(h)

protein-glutamine deamidase TGM2

protein-glutamine dopaminyltransferase TGM2

protein-glutamine histaminyltransferase TGM2

protein-glutamine n

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-117678 TG-2-IN-1 Inhibitor ≥98.0% 否
HY-12589 ZM39923 hydrochloride Inhibitor 98.19% 否
HY-RS14459 TGM2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16889 Tgm2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23331 Tgm2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-12589A ZM39923 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tgm2 NCBI NCBI:7052
Mus musculus Tgm2 NCBI NCBI:21817
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