PRM2 - protamine 2 Gene

中文名称：鱼精蛋白 2

种属: Homo sapiens

同用名: CT94.2

基因 ID: 5620 | 基因类型: protein coding

关于 PRM2

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:11,275,639-11,276,480 (from NCBI)

This gene has 2 transcripts (splice variants) and 44 orthologues. Restricted expression toward testis (RPKM 2357.8).

功能概要

在精子发生的单倍体阶段，鱼精蛋白替代精子染色质中的组蛋白，并且是许多脊椎动物精子核中的主要 DNA 结合蛋白。它们将精子 DNA 包装成高度浓缩的复合物，其体积不到体细胞核的 5%。许多哺乳动物物种只有一种鱼精蛋白 (鱼精蛋白 1) ；然而，包括人类和老鼠在内的少数物种有两个。该基因编码鱼精蛋白 2，它被切割后产生鱼精蛋白 2 肽家族。还发现了该基因的可变剪接转录物变体。[RefSeq 提供，2015 年 9 月]

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Sep 2015]

PRM2 基因产物(5)

mRNA	Protein	Name
NM_001286356.2	NP_001273285.1	protamine-2 isoform 2
NM_001286357.2	NP_001273286.1	protamine-2 isoform 3
NM_001286358.2	NP_001273287.1	protamine-2 isoform 4
NM_001286359.2	NP_001273288.1	protamine-2 isoform 5
NM_002762.4	NP_002753.2	protamine-2 isoform 1

PRM2 蛋白结构

Protamine_P2

0
102 a.a.

蛋白主名

其他名称

protamine-2

cancer/testis antigen family 94, member 2

PRM2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PRM2	P04554	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
种属内	PRM2	P04554	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
种属内	PRM2	P04554	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	32296183
种属内	PRM2	P04554	KRTAP17-1	Homo sapiens	Q9BYP8	Validated Y2H	32296183
种属内	PRM2	P04554	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Prey Pooling	32296183
种属内	PRM2	P04554	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Array	32296183
种属内	PRM2	P04554	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	32296183
种属内	PRM2	P04554	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183
种属内	PRM2	P04554	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Infertility

Varicocele

Scrotal Varices	Varicoceles
Varicocele Of Scrotum	Scrotal Varicocele

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome	Germinal Cell Aplasia
Del Castillo Syndrome	SPGFX1
X-Linked Spermatogenic Failure 1	Congenital Absence Of Germinal Epithelium Of Testes

Oligoasthenoteratozoospermia

Oat	Oligoasthenoteratospermia

Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens	CBAVD
Cavd	Congenital Bilateral Aplasia Of Vas Deferens
Congenital Bilateral Absence Of The Vas Deferens	Congenital Bilateral Agenesis Of Vas Deferens
Absence Of Vas Deferens	Absent Vasa
Congenital Absence Of Vas Deferens	Congenital Aplasia Of Vas Deferens
Absent Vas Deferens	Vas Deferens, Congenital Bilateral Absence

Oligospermia

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11165	PRM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PRM2	MGD	MGI:97766
Bos taurus	PRM2	VGNC	VGNC:58610
Rattus norvegicus	PRM2	RGD	RGD:3409

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRM2 - protamine 2 Gene

关于 PRM2

功能概要

PRM2 基因产物(5)

PRM2 蛋白结构

PRM2 蛋白互作信息

关联疾病

直系同源

热门区域

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PRM2 - protamine 2 Gene

关于 PRM2

功能概要

PRM2 基因产物(5)

PRM2 蛋白结构

PRM2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z