2. Gene
  3. Mettl3 - methyltransferase like 3 Gene

Mettl3 - methyltransferase like 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: M6A; Spo8; 2310024F18Rik

基因 ID: 56335 | 基因类型: protein coding

关于 Mettl3

功能概要

Enables mRNA (N6-adenosine)-methyltransferase activity. Involved in several processes, including RNA metabolic process; forebrain radial glial cell differentiation; and gamete generation. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in genitourinary system. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Mettl3 基因产物(1)

mRNA Protein Name
NM_019721.2 NP_062695.2 N6-adenosine-methyltransferase subunit METTL3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mRNA m(6)A methyltransferase activity IDA
IDA: 通过直接分析推断
24394384 MGI
enables mRNA m(6)A methyltransferase activity IMP
IMP: 通过突变表型推断
24209618 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
24394384 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RNA methylation IMP
IMP: 通过突变表型推断
28637692 MGI
involved in circadian rhythm IMP
IMP: 通过突变表型推断
24209618 MGI
involved in forebrain radial glial cell differentiation IMP
IMP: 通过突变表型推断
28965759 MGI
involved in gliogenesis IMP
IMP: 通过突变表型推断
28965759 MGI
involved in mRNA catabolic process IMP
IMP: 通过突变表型推断
28637692 MGI
involved in mRNA destabilization IMP
IMP: 通过突变表型推断
24394384 MGI
involved in mRNA modification IDA
IDA: 通过直接分析推断
24394384 MGI
involved in mRNA processing IDA
IDA: 通过直接分析推断
28965759 MGI
involved in mRNA processing IMP
IMP: 通过突变表型推断
24209618 MGI
NOT involved in mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
28637692 MGI
involved in mRNA splicing, via spliceosome IMP
IMP: 通过突变表型推断
25569111 MGI
involved in oogenesis IMP
IMP: 通过突变表型推断
32943573 MGI
involved in positive regulation of mRNA catabolic process IMP
IMP: 通过突变表型推断
33020597 MGI
involved in regulation of T cell differentiation IMP
IMP: 通过突变表型推断
28792938 MGI
involved in regulation of meiotic cell cycle IMP
IMP: 通过突变表型推断
28809392 MGI
involved in spermatogenesis IMP
IMP: 通过突变表型推断
28809392 MGI
involved in stem cell population maintenance IMP
IMP: 通过突变表型推断
24394384 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA N6-methyladenosine methyltransferase complex IDA
IDA: 通过直接分析推断
29547716 MGI
is active in nucleus IDA
IDA: 通过直接分析推断
28914256 MGI
located in nucleus IDA
IDA: 通过直接分析推断
28914256 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

N6-adenosine-methyltransferase subunit METTL3

MT-A70

N6-adenosine-methyltransferase 70 kDa subunit

m6a methyltransferase

methyltransferase-like protein 3

Mettl3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Mettl3 Q8C3P7 Mettl14 Mus musculus Q3UIK4
Anti Bait CoIP
24394384
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-156677 STC-15 Inhibitor 99.90% Phase 1
Pre-clinical Phase
生物活性分子 (24)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-134836 STM2457 Inhibitor 99.86% 否
HY-156773 STM3006 Inhibitor 98.71% 否
HY-162080 METTL1-WDR4-IN-1 Inhibitor 98.87% 否
HY-160415A WD6305 TFA Inhibitor 99.81% 否
HY-115717 UZH2 Inhibitor 98.91% 否
HY-W037893 METTL3 activator-1 Activator 99.38% 否
HY-153625 STM2120 Inhibitor 99.92% 否
HY-P10387 RSM3 Inhibitor 95.73% 否
HY-158404 METTL3-IN-8 Inhibitor 99.81% 否
HY-P10387A RSM3 TFA Inhibitor 98.83% 否
HY-159604 METTL3-IN-9 Inhibitor 95.30% 否
HY-174873 AF151 Degrader / 否
HY-134673B UZH1b Inhibitor 99.75% 否
HY-160415 WD6305 Inhibitor 98.06% 否
HY-158403 METTL3-IN-7 Inhibitor / 否
HY-148468 METTL3-IN-2 Inhibitor / 否
HY-148467 METTL3-IN-1 Inhibitor / 否
HY-156759 METTL3-IN-5 Inhibitor / 否
HY-168878 EP652 Inhibitor / 否
HY-W125425 METTL3 activator-1 free base Activator / 否
HY-148469 METTL3-IN-3 Inhibitor / 否
HY-174874 POI-4 / 否
HY-154997 7OQL Inhibitor / 否
HY-162930 PROTAC METTL3 degrader 1 Degrader / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mettl3 NCBI NCBI:56339
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