2. Gene
  3. Adar - adenosine deaminase, RNA-specific Gene

Adar - adenosine deaminase, RNA-specific Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Adar1; DRADA; mZaADAR; Adar1p110; Adar1p150

基因 ID: 56417 | 基因类型: protein coding

关于 Adar

功能概要

Enables double-stranded RNA Adenosine Deaminase activity. Involved in several processes, including adenosine to inosine editing; negative regulation of protein kinase activity by regulation of protein phosphorylation; and positive regulation of viral genome replication. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; immune system development; and regulation of gene expression. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Human papillomavirus infectious disease; dyschromatosis symmetrica hereditaria; and liver cirrhosis. Orthologous to human ADAR (Adenosine Deaminase RNA specific). [provided by Alliance of Genome Resources, Apr 2022]

Adar 基因产物(11)

mRNA Protein Name
NM_001038587.5 NP_001033676.2 double-stranded RNA-specific adenosine deaminase isoform 2
NM_001146296.2 NP_001139768.1 double-stranded RNA-specific adenosine deaminase isoform 3
NM_001357958.2 NP_001344887.1 double-stranded RNA-specific adenosine deaminase isoform 4
NM_001410658.1 NP_001397587.1 double-stranded RNA-specific adenosine deaminase isoform 5
NM_001410659.1 NP_001397588.1 double-stranded RNA-specific adenosine deaminase isoform 2
NM_001410660.1 NP_001397589.1 double-stranded RNA-specific adenosine deaminase isoform 6
NM_001410661.1 NP_001397590.1 double-stranded RNA-specific adenosine deaminase isoform 7
NM_001410662.1 NP_001397591.1 double-stranded RNA-specific adenosine deaminase isoform 8
NM_001410663.1 NP_001397592.1 double-stranded RNA-specific adenosine deaminase isoform 9
NM_001410664.1 NP_001397593.1 double-stranded RNA-specific adenosine deaminase isoform 9
NM_019655.4 NP_062629.3 double-stranded RNA-specific adenosine deaminase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18362360 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenosine to inosine editing IDA
IDA: 通过直接分析推断
17369310 MGI
acts upstream of or within adenosine to inosine editing IMP
IMP: 通过突变表型推断
14615479 MGI
acts upstream of apoptotic process IMP
IMP: 通过突变表型推断
14613934 MGI
involved in cellular response to virus IDA
IDA: 通过直接分析推断
24882218 MGI
acts upstream of or within definitive hemopoiesis IMP
IMP: 通过突变表型推断
14615479 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: 通过突变表型推断
11099415 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: 通过突变表型推断
19805087 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: 通过突变表型推断
19060901 MGI
acts upstream of hepatocyte apoptotic process IMP
IMP: 通过突变表型推断
14613934 MGI
acts upstream of or within miRNA processing IMP
IMP: 通过突变表型推断
23622242 MGI
acts upstream of or within negative regulation of hepatocyte apoptotic process IMP
IMP: 通过突变表型推断
14613934 MGI
acts upstream of or within negative regulation of post-transcriptional gene silencing by regulatory ncRNA IMP
IMP: 通过突变表型推断
15556947 MGI
involved in negative regulation of protein kinase activity by regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
18362360 MGI
acts upstream of or within negative regulation of type I interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
19060901 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: 通过突变表型推断
23123729 MGI
involved in positive regulation of viral genome replication IMP
IMP: 通过突变表型推断
18362360 MGI
acts upstream of or within somatic diversification of immune receptors via somatic mutation IDA
IDA: 通过直接分析推断
23209284 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
14613934 MGI
located in nucleolus IDA
IDA: 通过直接分析推断
14613934 MGI
located in nucleus IDA
IDA: 通过直接分析推断
14613934 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

double-stranded RNA-specific adenosine deaminase

RNA adenosine deaminase 1

RNA-specific adenosine deaminase p110 form

RNA-specific adenosine deaminase p150 form

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-115686 8-Azaadenosine Inhibitor 99.94% 否
HY-145443 Fludarabine-Cl Inhibitor 99.71% 否
HY-145442 8-Azanebularine Inhibitor 99.33% 否
HY-RS17682 Adar Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS00317 ADAR Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-175243 ADAR1-IN-1 / 否
HY-RS24143 Adar Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adar NCBI NCBI:103
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