Ikbke - inhibitor of kappaB kinase epsilon Gene

中文名称：kappaB 激酶 ε 抑制因子

种属: Mus musculus

同用名: Ikki; IKK-E; IKK-i; IKKepsilon

关于 Ikbke

功能概要

该基因编码的蛋白可启动 IkappaB 激酶活性； K48 连接的多聚泛素修饰依赖性蛋白结合活性；和泛素蛋白连接酶结合活性。参与多个过程，包括白介素 17 介导的信号通路； mRNA稳定； I 型干扰素介导的信号通路的正调控。预测位于PML体和线粒体膜。预计在细胞质中有活性。以多种结构表达，包括未来的大脑；感觉器官；下颌下腺原基；胸腺原基；和鼻甲骨原基。与人 IKBKE 同源（核因子 kappa B 激酶亚基 epsilon 的抑制剂）。 [由基因组资源联盟提供，2022 年 4 月]

Enables IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including interleukin-17-mediated signaling pathway; mRNA stabilization; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in PML body and mitochondrial membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including future brain; sensory organ; submandibular gland primordium; thymus primordium; and turbinate bone primordium. Orthologous to human IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon). [provided by Alliance of Genome Resources, Apr 2022]