2. Gene
  3. Anxa2 - annexin A2 Gene

Anxa2 - annexin A2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: ANX2

基因 ID: 56611 | 基因类型: protein coding

关于 Anxa2

功能概要

Enables bone sialoprotein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of fibroblast proliferation; protein localization to plasma membrane; and response to thyroid hormone. Located in several cellular components, including macropinosome; membrane raft; and ruffle. Part of protein-containing complex. Biomarker of hyperthyroidism; hypothyroidism; and renal cell carcinoma. Human ortholog(s) of this gene implicated in osteonecrosis. Orthologous to several human genes including AnxA2 (annexin A2). [provided by Alliance of Genome Resources, Apr 2022]

Anxa2 基因产物(1)

mRNA Protein Name
NM_019905.1 NP_063970.1 annexin A2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables bone sialoprotein binding IPI
IPI: 通过物理相互作用推断
23525114 RGD
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: 通过直接分析推断
14734570 RGD
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
18332131 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in body fluid secretion IMP
IMP: 通过突变表型推断
18332131 RGD
involved in positive regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
19193640 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
19193640 RGD
involved in protein localization to plasma membrane IMP
IMP: 通过突变表型推断
19193640 RGD
involved in response to thyroid hormone IEP
IEP: 通过表达模式推断
9022675 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell cortex IDA
IDA: 通过直接分析推断
19193640 RGD
located in cytosol IDA
IDA: 通过直接分析推断
14499952 RGD
located in macropinosome IDA
IDA: 通过直接分析推断
19193640 RGD
located in membrane IDA
IDA: 通过直接分析推断
23525114 RGD
located in membrane raft IDA
IDA: 通过直接分析推断
14499952 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
14734570 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
23525114 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
15823548 RGD
located in ruffle IDA
IDA: 通过直接分析推断
19193640 RGD
located in vesicle IDA
IDA: 通过直接分析推断
19193640 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

annexin A2

PAP-IV

annexin-2

calpactin I heavy chain

calpactin-1 heavy chain

chromobindin-8

lipocortin II

p36

placental anticoagulant protein IV

protein I

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-126849 3-Morpholinosydnonimine Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Anxa2 NCBI NCBI:302
Mus musculus Anxa2 NCBI NCBI:12306
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