2. Apoptosis
  3. MDM-2/p53
  4. 3-Morpholinosydnonimine

3-Morpholinosydnonimine  (Synonyms: SIN-1; Linsidomine)

目录号: HY-126849
产品使用指南

摩尔计算器

3-Morpholinosydnonimine (SIN-1; Linsidomine) 是一种自发的 ROS/RNS 发生因子和过氧亚硝酸盐供体。3-Morpholinosydnonimine 能够抑制肥大软骨细胞活力，并诱导坏死 (necrosis)。3-Morpholinosydnonimine 诱导 p53 依赖性凋亡 (apoptosis)，诱导 p53 积聚和激活 MAPK 磷酸化。

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3-Morpholinosydnonimine Chemical Structure

3-Morpholinosydnonimine Chemical Structure

CAS No. : 33876-97-0

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3-Morpholinosydnonimine 的其他形式现货产品:

Customer Review

Other Forms of 3-Morpholinosydnonimine:

3-Morpholinosydnonimine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3-Morpholinosydnonimine (SIN-1; Linsidomine) is a spontaneous ROS/RNS generator and a peroxynitrite donor. 3-Morpholinosydnonimine inhibits hypertrophic chondrocytes activity and induces necrosis. 3-Morpholinosydnonimine induces p53-dependent apoptosis, induces p53 accumulation and activates MAPK phosphorylation[1][2].

体外研究
(In Vitro)

3-Morpholinosydnonimine (1,3,5 mM; 24 h) 抑制肥厚性软骨细胞活力[1]。
3-Morpholinosydnonimine (3 mM 和 5 mM; 24 h) 诱导肥大软骨细胞坏死死亡，同时诱导 ATDC5 细胞和 C28/I2 细胞凋亡死亡[1]。
3-Morpholinosydnonimine (50 μM, 200 μM, 400 μM; 6 h) 在富含神经元的小鼠端脑细胞中诱导 p53 的表达迅速增加，并诱导 p53 依赖的凋亡[2]。
3-Morpholinosydnonimine (200 μM; 6 h) 通过 p21(ras) 激活诱导 p53 积累[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3-Morpholinosydnonimine 相关抗体:

Cell Viability Assay[1]

Cell Line: Hypertrophic chondrocytes
Concentration: 0 mM, 1 mM, 3 mM, and 5 mM
Incubation Time: 0 h, 4 h, 8 h, 12 h, and 24 h
Result: Decreased the cellular viability by 30%, 50%, and 80% respectively at 1, 3, and 5 mM.

Western Blot Analysis[2]

Cell Line: Mouse primary neural cells
Concentration: 200 μM
Incubation Time: 6 h
Result: Induced p53 accumulation.
分子量

170.17

Formula

C6H10N4O2
CAS 号
中文名称

林西多明
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3-Morpholinosydnonimine 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Morpholinosydnonimine33876-97-0SIN-1 Linsidomine林西多明SIN1SIN 1MDM-2/p53Inhibitorinhibitorinhibit

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