2. Gene
  3. Gsk3b - glycogen synthase kinase 3 beta Gene

Gsk3b - glycogen synthase kinase 3 beta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: GSK3; GSK-3; GSK-3beta; 7330414F15Rik; 8430431H08Rik

基因 ID: 56637 | 基因类型: protein coding

关于 Gsk3b

功能概要

Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and protein kinase activity. Involved in several processes, including apoptotic signaling pathway; negative regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of nitrogen compound metabolic process; and regulation of neuron projection development. Located in several cellular components, including dendritic shaft; glutamatergic synapse; and postsynaptic density. Part of Wnt signalosome; beta-catenin destruction complex; and ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Apr 2022]

Gsk3b 基因产物(2)

mRNA Protein Name
NM_001347232.1 NP_001334161.1 glycogen synthase kinase-3 beta isoform 2
NM_019827.7 NP_062801.1 glycogen synthase kinase-3 beta isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-catenin binding IPI
IPI: 通过物理相互作用推断
12874278 MGI
enables dynein complex binding IPI
IPI: 通过物理相互作用推断
28057765 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9554852 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
14730361 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
22899650 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12805290 MGI
enables protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
16543145 MGI
enables tau-protein kinase activity IDA
IDA: 通过直接分析推断
15192701 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within ER overload response IDA
IDA: 通过直接分析推断
14744935 MGI
acts upstream of or within Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
23074275 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
10894547 MGI
acts upstream of positive effect autosome genomic imprinting IMP
IMP: 通过突变表型推断
21047779 MGI
acts upstream of axon extension IGI
IGI: 通过遗传相互作用推断
24623780 MGI
acts upstream of or within axonogenesis IGI
IGI: 通过遗传相互作用推断
18716223 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
15282335 MGI
acts upstream of or within canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
16815997 MGI
acts upstream of or within cell migration IGI
IGI: 通过遗传相互作用推断
17986005 MGI
involved in cellular response to glucocorticoid stimulus IGI
IGI: 通过遗传相互作用推断
20371704 MGI
acts upstream of or within cellular response to hepatocyte growth factor stimulus IDA
IDA: 通过直接分析推断
21072211 MGI
involved in cellular response to interleukin-3 IDA
IDA: 通过直接分析推断
16543145 MGI
involved in circadian rhythm IMP
IMP: 通过突变表型推断
20123978 MGI
involved in extrinsic apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
20371704 MGI
involved in extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: 通过直接分析推断
16543145 MGI
acts upstream of or within fat cell differentiation IDA
IDA: 通过直接分析推断
12502791 MGI
involved in insulin receptor signaling pathway IDA
IDA: 通过直接分析推断
28057765 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
23028846 MGI
involved in meiosis I IMP
IMP: 通过突变表型推断
29228573 MGI
acts upstream of or within myoblast fusion IDA
IDA: 通过直接分析推断
15282335 MGI
acts upstream of or within myoblast fusion IGI
IGI: 通过遗传相互作用推断
15282335 MGI
acts upstream of or within myotube differentiation IGI
IGI: 通过遗传相互作用推断
15282335 MGI
involved in negative regulation of TOR signaling IGI
IGI: 通过遗传相互作用推断
26160071 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
10894547 MGI
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
12154096 MGI
acts upstream of or within negative regulation of cardiac muscle hypertrophy IDA
IDA: 通过直接分析推断
11782539 MGI
involved in negative regulation of glycogen biosynthetic process IMP
IMP: 通过突变表型推断
31553910 MGI
acts upstream of or within negative regulation of neuron maturation IGI
IGI: 通过遗传相互作用推断
23015435 MGI
acts upstream of or within negative regulation of neuron projection development IGI
IGI: 通过遗传相互作用推断
23015435 MGI
acts upstream of or within negative regulation of neuron projection development IMP
IMP: 通过突变表型推断
23015435 MGI
involved in negative regulation of protein localization to centrosome IMP
IMP: 通过突变表型推断
28057765 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
17986005 MGI
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
20123978 MGI
involved in peptidyl-serine phosphorylation IGI
IGI: 通过遗传相互作用推断
16537926 MGI
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
29228573 MGI
involved in phosphorylation IMP
IMP: 通过突变表型推断
17182001 MGI
involved in positive regulation of autophagy IDA
IDA: 通过直接分析推断
22539723 MGI
involved in positive regulation of autophagy IGI
IGI: 通过遗传相互作用推断
26160071 MGI
acts upstream of or within positive regulation of axon extension IGI
IGI: 通过遗传相互作用推断
24623780 MGI
involved in positive regulation of cardiac muscle cell differentiation IMP
IMP: 通过突变表型推断
24974728 MGI
involved in positive regulation of cilium assembly IMP
IMP: 通过突变表型推断
25860027 MGI
involved in positive regulation of gene expression IGI
IGI: 通过遗传相互作用推断
20371704 MGI
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
24974728 MGI
involved in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
IDA: 通过直接分析推断
16543145 MGI
acts upstream of or within positive regulation of peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
17986005 MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
IGI: 通过遗传相互作用推断
22660580 MGI
acts upstream of or within positive regulation of protein binding IDA
IDA: 通过直接分析推断
19141611 MGI
involved in positive regulation of protein localization to cilium IMP
IMP: 通过突变表型推断
25860027 MGI
acts upstream of or within positive regulation of stem cell differentiation IMP
IMP: 通过突变表型推断
22064483 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
23015435 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
21047779 MGI
acts upstream of or within protein export from nucleus IDA
IDA: 通过直接分析推断
11782539 MGI
acts upstream of or within protein localization to microtubule IGI
IGI: 通过遗传相互作用推断
18716223 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
12432063 MGI
acts upstream of or within protein phosphorylation IGI
IGI: 通过遗传相互作用推断
19141611 MGI
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
16543145 MGI
acts upstream of or within re-entry into mitotic cell cycle IDA
IDA: 通过直接分析推断
12502791 MGI
involved in regulation of apoptotic process IMP
IMP: 通过突变表型推断
12154096 MGI
acts upstream of or within regulation of cell growth IMP
IMP: 通过突变表型推断
18824542 MGI
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
28556462 MGI
involved in regulation of long-term synaptic potentiation IMP
IMP: 通过突变表型推断
28556462 MGI
involved in regulation of microtubule-based process IDA
IDA: 通过直接分析推断
21295697 MGI
acts upstream of or within regulation of neuron projection development IGI
IGI: 通过遗传相互作用推断
24227739 MGI
acts upstream of stem cell differentiation IMP
IMP: 通过突变表型推断
22064483 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
23015435 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Wnt signalosome IDA
IDA: 通过直接分析推断
22899650 MGI
part of beta-catenin destruction complex IDA
IDA: 通过直接分析推断
10318824 MGI
located in cytosol IDA
IDA: 通过直接分析推断
12502791 MGI
located in dendritic shaft IDA
IDA: 通过直接分析推断
12805290 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
20111716 MGI
located in growth cone IDA
IDA: 通过直接分析推断
12805290 MGI
is active in meiotic spindle IDA
IDA: 通过直接分析推断
29228573 MGI
located in membrane-bounded organelle IDA
IDA: 通过直接分析推断
12805290 MGI
located in neuronal cell body IDA
IDA: 通过直接分析推断
12805290 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12502791 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
20890042 MGI
is active in postsynaptic density IDA
IDA: 通过直接分析推断
20111716 MGI
located in postsynaptic density IDA
IDA: 通过直接分析推断
17114649 MGI
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
21709260 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

glycogen synthase kinase-3 beta

serine/threonine-protein kinase GSK3B

Gsk3b 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Gsk3b Q9WV60 Epm2a Mus musculus Q9WUA5
Anti Bait CoIP
16959610
种属内
Gsk3b Q9WV60 Ctnnb1 Mus musculus Q02248
Protein Kinase Assay
19107203
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Gsk3b 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73090 GSK-3 beta Protein, Mouse (sf9, His) Q9WV60 (M1-T420) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112388 GSK-3b Inhibitor XI Inhibitor 99.10% 否
HY-RS05865 GSK3B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17170 Gsk3b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23620 Gsk3b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gsk3b NCBI NCBI:2932
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