Litaf - LPS-induced TN factor Gene

种属: Mus musculus

同用名: TBX1; N4WBP3; 3222402J11Rik

关于 Litaf

功能概要

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; WW domain binding activity; and zinc ion binding activity. Acts upstream of or within cellular response to lipopolysaccharide; negative regulation of NIK/NF-kappaB signaling; and regulation of cytokine production. Predicted to be located in several cellular components, including cytoplasmic side of endosome membrane; cytoplasmic side of lysosomal membrane; and cytoplasmic side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; retina nuclear layer; and vibrissa. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1C. Orthologous to human LITAF (lipopolysaccharide induced TNF factor). [provided by Alliance of Genome Resources, Apr 2022]