PAK6 - p21 (RAC1) activated kinase 6 Gene

中文名称：p21 (RAC1) 激活激酶 6

种属: Homo sapiens

同用名: PAK5

关于 PAK6

功能概要

该基因编码 p21 刺激的丝氨酸/苏氨酸蛋白激酶家族的一个成员，该激酶家族包含一个氨基末端 Cdc42/Rac 相互作用结合 (CRIB) 结构域和一个羧基末端激酶结构域。这些激酶在许多细胞过程中起作用，包括细胞骨架重排、细胞凋亡和丝裂原活化蛋白 (MAP) 激酶信号通路。由该基因编码的蛋白质与雄激素受体 (AR) 相互作用并转移到细胞核，参与转录调控。该基因表达的变化与前列腺癌有关。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 12 月]

This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including Cytoskeleton rearrangement, Apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with Androgen Receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]