BMAL2 - basic helix-loop-helix ARNT like 2 Gene

中文名称：基本的螺旋-环-螺旋 ARNT 样 2

种属: Homo sapiens

同用名: CLIF; MOP9; PASD9; ARNTL2; bHLHe6

基因 ID: 56938 | 基因类型: protein coding

关于 BMAL2

Cytogenetic location: 12p11.23 Genomic coordinates (GRCh38): 12:27,332,836-27,425,286 (from NCBI)

This gene has 9 transcripts (splice variants), 245 orthologues and 6 paralogues. Broad expression in esophagus (RPKM 6.4), appendix (RPKM 3.2) and 17 other tissues.

功能概要

该基因编码属于 PAS (PER、ARNT、SIM) 超家族的基本螺旋-环-螺旋转录因子。 PAS 蛋白在适应低大气和细胞氧气水平、暴露于某些环境污染物以及光和温度的昼夜振荡方面发挥着重要作用。该蛋白与昼夜节律 CLOCK 蛋白、结构相关的 MOP4 和缺氧诱导因子 (如 HIF1alpha) 形成转录活性异二聚体。与其作为昼夜节律和缺氧因子的生物学相关伙伴的作用一致，该蛋白质在大脑区域共表达，例如丘脑、下丘脑和杏仁核。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 10 月]

This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

BMAL2 基因产物(11)

mRNA	Protein	Name
NM_001248002.3	NP_001234931.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 2
NM_001248003.3	NP_001234932.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 3
NM_001248004.3	NP_001234933.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 4
NM_001248005.3	NP_001234934.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 5
NM_001394524.1	NP_001381453.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 6
NM_001394525.1	NP_001381454.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 7
NM_001394526.1	NP_001381455.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 8
NM_001394527.1	NP_001381456.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 9
NM_001394528.1	NP_001381457.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 10
NM_001394529.1	NP_001381458.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 11
NM_020183.6	NP_064568.3	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	12055078	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	15147242	GOA
enables E-box binding	IDA IDA: 通过直接分析推断	12738229	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	15147242	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11018023	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in circadian regulation of gene expression	IDA IDA: 通过直接分析推断	10864977	GOA
acts upstream of or within circadian rhythm	IDA IDA: 通过直接分析推断	10864977	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	10864977	GOA
involved in positive regulation of circadian rhythm	IDA IDA: 通过直接分析推断	12738229	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15147242	GOA
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12055078	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CLOCK-BMAL transcription complex	IPI IPI: 通过物理相互作用推断	10864977	GOA
located in nucleus	IDA IDA: 通过直接分析推断	12055078	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BMAL2 蛋白结构

HLH

PAS

PAS_11

0
100
200
300
400
500
600
636 a.a.

蛋白主名

其他名称

aryl hydrocarbon receptor nuclear translocator-like protein 2

CYCLE-like factor

BMAL2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BMAL2	Q8WYA1	CLOCK	Homo sapiens	O15516	Anti Tag CoIP	33961781
种属内	BMAL2	Q8WYA1	CLOCK	Homo sapiens	O15516	Y2H	11018023

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hepatorenal Syndrome

Hepato-Renal Syndrome	Hepatorenal Failure
Hrf - [Hepatorenal Failure]	Hepatorenal Degeneration
Hepatic Renal Syndrome	Hepatic Renal Failure
Renal Hepatic Failure	Urohepatic Syndrome

Hepatic Vascular Disease

Vascular Disorder Of Liver

Acute Kidney Failure

Acute Renal Failure	Acute Kidney Injury
Renal Failure Acute	Kidney Failure, Acute
Pre-Renal Acute Kidney Injury	Nontraumatic Acute Kidney Injury
Aki - [Acute Kidney Injury]	Arf - [Acute Kidney Failure]
Acute Kidney Disease	Acute Kidney Impairment
Acute Ischaemic Renal Failure	Acute Hypoxic Kidney Failure
Acute Kidney Shutdown	Acute Renal Oedema
Acute Renal Impairment	Acute Kidney Collapse
Acute Necrotising Kidney	Acute Renal Suppression

Esophageal Varix

Esophageal Varices	Bleeding Esophageal Varices
Bleeding Oesophageal Varices	Esophageal Varices In Disease Classified Elsewhere, With Bleeding
Esophageal Varices With Bleeding	Esophageal Varices With Bleeding In Disease Ec
Esophageal Varices Without Bleeding	Esophageal Varices Without Mention Of Bleeding

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01530	BMAL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	BMAL2	VGNC	VGNC:83500
Rattus norvegicus	BMAL2	RGD	RGD:620230
Mus musculus	BMAL2	MGD	MGI:2684845
Bos taurus	BMAL2	VGNC	VGNC:49075
Canis familiaris	BMAL2	VGNC	VGNC:48873
Macaca mulatta	BMAL2	VGNC	VGNC:99889

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BMAL2 - basic helix-loop-helix ARNT like 2 Gene

关于 BMAL2

功能概要

BMAL2 基因产物(11)

BMAL2 蛋白结构

BMAL2 蛋白互作信息

关联疾病

直系同源

热门区域

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BMAL2 - basic helix-loop-helix ARNT like 2 Gene

关于 BMAL2

功能概要

BMAL2 基因产物(11)

BMAL2 蛋白结构

BMAL2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z