2. Gene
  3. ACKR3 - atypical chemokine receptor 3 Gene

ACKR3 - atypical chemokine receptor 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：非典型趋化因子受体 3

种属: Homo sapiens

同用名: RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159

基因 ID: 57007 | 基因类型: protein coding

关于 ACKR3

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:236,537,122-236,582,354 (from NCBI)

This gene has 2 transcripts (splice variants), 252 orthologues, 23 paralogues and is associated with 53 phenotypes. Broad expression in placenta (RPKM 50.1), urinary bladder (RPKM 36.9) and 22 other tissues.

功能概要

该基因编码 G 蛋白偶联受体家族的一个成员。虽然这种蛋白质早先被认为是血管活性肠肽 (VIP) 的受体，但现在它被认为是一种孤儿受体，因为它的内源性配体尚未确定。该蛋白也是人类免疫缺陷病毒 (HIV) 的辅助受体。已在脂肪瘤中观察到涉及该基因和 12 号染色体上的 HMGA2 的易位。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an Orphan Receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]

ACKR3 基因产物(6)

mRNA Protein Name
XM_005246098.4 XP_005246155.1 atypical chemokine receptor 3 isoform X1
XM_047445136.1 XP_047301092.1 atypical chemokine receptor 3 isoform X1
NM_001047841.1
NM_020311.3 NP_064707.1 atypical chemokine receptor 3
XM_005246097.4 XP_005246154.1 atypical chemokine receptor 3 isoform X1
XM_047445135.1 XP_047301091.1 atypical chemokine receptor 3 isoform X1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables C-X-C chemokine binding IMP
IMP: 通过突变表型推断
22300987 GOA
enables C-X-C chemokine receptor activity IMP
IMP: 通过突变表型推断
20388803 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19380869 GOA
enables scavenger receptor activity IMP
IMP: 通过突变表型推断
22300987 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chemokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
20388803 GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
20388803 GOA
involved in oculomotor nerve development IMP
IMP: 通过突变表型推断
31211835 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
22300987 GOA
involved in receptor internalization IMP
IMP: 通过突变表型推断
22300987 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
22457824 GOA
located in clathrin-coated pit IDA
IDA: 通过直接分析推断
22457824 GOA
located in endosome IDA
IDA: 通过直接分析推断
22300987 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
22300987 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ACKR3 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (62 - 315)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
蛋白主名 其他名称

atypical chemokine receptor 3

C-X-C chemokine receptor type 7

G protein-coupled receptor

G-protein coupled receptor 159

G-protein coupled receptor RDC1 homolog

chemokine (C-X-C motif) receptor 7

chemokine orphan receptor 1

ACKR3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ACKR3 P25106 CXCR4 Homo sapiens P61073
PLA
28862946
种属内
ACKR3 P25106 CXCR4 Homo sapiens P61073
Confocal
21730065
种属内
ACKR3 P25106 CXCR4 Homo sapiens P61073
BRET
19380869
种属内
ACKR3 P25106 CXCR4 Homo sapiens P61073
PLA
29386406
种属内
ACKR3 P25106 CXCR4 Homo sapiens P61073
PLA
27331810
种属内
ACKR3 P25106 AVPR1A Homo sapiens P37288
PLA
29386406
种属内
ACKR3 P25106 AVPR1A Homo sapiens P37288
BRET
29386406
种属内
ACKR3 P25106 AVPR1A Homo sapiens P37288
Anti Tag CoIP
29386406
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ACKR3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700537 ACKR3 Protein, Human (His-SUMO) P25106 (M1-K40) ≥95%

ACKR3 抗体

目录号 产品名 应用 反应物种
HY-P83212 RDC1 Antibody (YA2957) WB Human, Mouse, Rat
HY-P84210 CXCR7 Antibody (YA3907) IHC-P, ICC/IF, FC, ELISA Human

关联疾病

疾病名称 别名
Oculomotor-Abducens Synkinesis

OCABSN
Whim Syndrome 1

Whim Syndrome

Whims

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis

WHIMS1

Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1

Myelokathexis, Isolated

Wilm

Warts-Infections-Leukopenia-Myelokatexis Syndrome

Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
Glioma
Ptosis

Blepharoptosis

Drooping Eyelid

Droopy Eyelid

Ptosis Of Eyelid

Paralysis Of Levator Palpebrae Superioris
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-123813 CCX-777 Agonist 98.73% 否
HY-P10333A LIH383 TFA Agonist 99.83% 否
HY-RS00162 ACKR3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-159582 ACKR3 agonist 1 Agonist / 否
HY-161414 trans-VUF25471 Agonist / 否
HY-D2201 Fluorescent ACKR3 antagonist 1 / 否
HY-P10333 LIH383 Agonist / 否
HY-RS00163 Ackr3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00164 Ackr3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ACKR3 MGD MGI:109562
Canis familiaris ACKR3 VGNC VGNC:37509
Rattus norvegicus ACKR3 RGD RGD:620601
Bos taurus ACKR3 VGNC VGNC:25541
Felis catus ACKR3 VGNC VGNC:59511
Macaca mulatta ACKR3 VGNC VGNC:69513
Others ACKR3 NCBI
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