Adam17 - ADAM metallopeptidase domain 17 Gene

中文名称：ADAM 金属肽酶结构域 17

种属: Rattus norvegicus

同用名: TACE

关于 Adam17

功能概要

预计该基因编码的蛋白可启动 PDZ 域绑定活动；参与淀粉样前体蛋白分解代谢过程的金属内肽酶活性；和信号受体结合活性。参与多个过程，包括细胞凋亡过程的调节；调节信号转导；和对抗肿瘤药物的反应。位于多个细胞成分中，包括细胞的顶端部分；细胞表面；和细胞质囊泡。阿尔茨海默病的生物标志物；充血性心力衰竭;和胸主动脉瘤。该基因的人类直系同源物与阿尔茨海默病有关；炎症性肠病;和 2 型糖尿病。与人类 ADAM17（ADAM 金属肽酶结构域 17）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable PDZ domain binding activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; and signaling receptor binding activity. Involved in several processes, including regulation of apoptotic process; regulation of signal transduction; and response to antineoplastic agent. Located in several cellular components, including apical part of cell; cell surface; and cytoplasmic vesicle. Biomarker of Alzheimer's disease; congestive heart failure; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17). [provided by Alliance of Genome Resources, Apr 2022]