PCBP4 - poly(rC) binding protein 4 Gene

中文名称：聚 (rC) 结合蛋白 4

种属: Homo sapiens

同用名: CBP; LIP4; MCG10

关于 PCBP4

功能概要

该基因编码 KH 结构域蛋白亚家族的一个成员。该亚家族的蛋白质，也称为 alpha-CP，与 RNA 结合，对富含 C 的嘧啶区域具有特异性。 Alpha-CP 在转录后活动中发挥重要作用，并具有不同的细胞分布。该基因由 p53 肿瘤抑制因子诱导，编码的蛋白质可通过诱导 G (2) -M 细胞凋亡和细胞周期停滞来抑制细胞增殖。该基因的蛋白质存在于细胞质中，但它缺乏在其他亚科成员中发现的核定位信号。已经描述了多个选择性剪接的转录物变体，但只有一些变体的全长性质已经确定。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing Apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in Other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]