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  3. RAB25 - RAB25, member RAS oncogene family Gene

RAB25 - RAB25, member RAS oncogene family Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAB25，RAS 致癌基因家族成员

种属: Homo sapiens

同用名: CATX-8; RAB11C

基因 ID: 57111 | 基因类型: protein coding

关于 RAB25

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:156,061,160-156,070,504 (from NCBI)

This gene has 5 transcripts (splice variants), 265 orthologues and 68 paralogues. Biased expression in esophagus (RPKM 128.3), skin (RPKM 60.6) and 12 other tissues.

功能概要

该基因编码的蛋白质是小 GTP 酶 Ras 超家族的成员。编码的蛋白质参与膜运输和细胞存活。已发现该基因是肿瘤抑制基因和致癌基因，具体取决于上下文。已发现该基因的两种变体，一种编码蛋白质，另一种不编码。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is a member of the Ras superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the Other not, have been found for this gene. [provided by RefSeq, Nov 2015]

RAB25 基因产物(1)

mRNA Protein Name
NM_020387.4 NP_065120.2 ras-related protein Rab-25 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables myosin V binding IPI
IPI: 通过物理相互作用推断
24006491 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17925226 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15502842 GOA
involved in positive regulation of epithelial cell migration IMP
IMP: 通过突变表型推断
22613965 GOA
involved in pseudopodium organization IDA
IDA: 通过直接分析推断
17925226 GOA
involved in regulation of vesicle-mediated transport IMP
IMP: 通过突变表型推断
22613965 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
17925226 GOA
located in pseudopodium IDA
IDA: 通过直接分析推断
17925226 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAB25 蛋白结构

Ras

Ras: Ras family (14 - 173)

  • 0
  • 100
  • 200
  • 213 a.a.
蛋白主名 其他名称

ras-related protein Rab-25

RAB25 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RAB25 P57735 RAB11FIP2 Homo sapiens Q7L804
Validated Y2H
32296183
种属内
RAB25 P57735 MYO5B Homo sapiens Q9ULV0-2
Validated Y2H
32296183
种属内
RAB25 P57735 SH3BP5L Homo sapiens Q7L8J4
Y2H Prey Pooling
32296183
种属内
RAB25 P57735 SH3BP5L Homo sapiens Q7L8J4
Validated Y2H
32296183
种属内
RAB25 P57735 SH3BP5L Homo sapiens Q7L8J4
Y2H Array
32296183
种属间
RAB25 P57735 P08563-PRO_0000041303 Rubella virus P08563-PRO_0000041303
Pull Down
24955142
种属间: 跨种属相互作用 种属内: 同种属相互作用

RAB25 抗体

目录号 产品名 应用 反应物种
HY-P82136 Rab25 Antibody (YA1881) WB Human
HY-P85343 Rab25 Antibody (YA5035) WB Human

关联疾病

疾病名称 别名
Binocular Vision Disease

Simultaneous Visual Perception Without Fusion
Corneal Dystrophy, Posterior Polymorphous, 4

PPCD4

Posterior Polymorphous Corneal Dystrophy 4
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11535 RAB25 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19544 Lamtor2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RAB25 VGNC VGNC:45265
Rattus norvegicus RAB25 RGD RGD:1308447
Mus musculus RAB25 MGD MGI:1858203
Bos taurus RAB25 VGNC VGNC:33632
Macaca mulatta RAB25 VGNC VGNC:81525
Felis catus RAB25 VGNC VGNC:97585
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