SLURP1 - secreted LY6/PLAUR domain containing 1 Gene

中文名称：含分泌的 LY6/PLAUR 结构域 1

种属: Homo sapiens

同用名: ARS; MDM; ANUP; ArsB; LY6LS; LY6-MT

基因 ID: 57152 | 基因类型: protein coding

关于 SLURP1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:142,740,949-142,742,406 (from NCBI)

This gene has 1 transcript (splice variant), 80 orthologues, 3 paralogues and is associated with 4 phenotypes. Restricted expression toward esophagus (RPKM 167.7).

功能概要

该基因编码的蛋白质是 Ly6/uPAR 家族的成员，但缺少 GPI 锚定信号序列。人们认为这种分泌的蛋白质具有抗肿瘤活性。该基因的突变与罕见的常染色体隐性皮肤病 Mal de Meleda 有关。该基因映射到与 Ly6/uPAR 糖蛋白受体家族的几个成员相同的染色体区域。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]

SLURP1 基因产物(1)

mRNA	Protein	Name
NM_020427.3	NP_065160.1	secreted Ly-6/uPAR-related protein 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables acetylcholine receptor activator activity	IDA IDA: 通过直接分析推断	14506129	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25168896	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of cell migration	IDA IDA: 通过直接分析推断	25168896	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	25168896	GOA
involved in urokinase plasminogen activator signaling pathway	IDA IDA: 通过直接分析推断	25168896	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	25919322	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLURP1 蛋白结构

UPAR_LY6

0
103 a.a.

蛋白主名

其他名称

secreted Ly-6/uPAR-related protein 1

ARS(component B)-81/S

SLURP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SLURP1	P55000	PLAU	Homo sapiens	P00749	Anti Tag CoIP	33961781
种属内	SLURP1	P55000	PLAU	Homo sapiens	P00749	ELISA	25168896
种属内	SLURP1	P55000	CHRNA7	Homo sapiens	P36544	Affinity Chrom	26905431

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mal De Meleda

Meleda Disease	Keratosis Palmoplantaris Transgrediens Of Siemens
MDM	Transgrediens Palmoplantar Keratoderma Of Siemens
Acroerythrokeratoderma	Keratosis Palmoplantaris Transgradiens Of Siemens

Palmoplantar Keratoderma, Norrbotten Recessive Type

PPKNR	Hereditary Palmoplantar Keratoderma, Gamborg-Nielsen Type
Hereditary Palmoplantar Hyperkeratosis, Gamborg-Nielsen Type	Ppk, Gamborg-Nielsen Type
Keratoderma, Palmoplantar, Norrbotten Recessive Type

Palmoplantar Keratosis

Palmoplantar Keratoderma	Keratosis Palmaris Et Plantaris
Palmo-Plantar Keratodermas	Keratoderma, Palmoplantar
Keratoderma Palmoplantar	Keratoderma, Palmoplantar, Diffuse
Hyperkeratosis Of Palms And Soles	Palmoplantar Hyperkeratosis

Necrotizing Ulcerative Gingivitis

Acute Necrotizing Ulcerative Gingivitis	Anug
Vincent Angina	Vincent'S Disease
Acute Necrotising Ulcerative Gingivitis	Acute Necrotising Ulcerative Gingivostomatitis
Acute Necrotizing Ulcerative Gingivostomatitis	Acute Ulceromembranous Gingivitis
Angina - Vincents	Early Acute Necrotising Gingivitis
Trench Mouth	Vincent'S Angina
Vincent'S Angina - Pharyngitis	Vincent'S Infection, Any Site
Acute Membranous Gingivitis	Fusospirillary Gingivitis
Fusospirillosis	Phagedenic Gingivitis
Vincent'S Gingivitis	Vincent'S Infection
Vincent'S Stomatitis	Gingivitis, Necrotizing Ulcerative

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Palmoplantar Keratoderma, Nonepidermolytic, Focal 1

Focal Nonepidermolytic Palmoplantar Keratoderma	Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma
FNEPPK1	Ppkfne
Keratoderma, Focal Nonepidermolytic Palmoplantar	Palmoplantar Keratoderma, Nonepidermolytic, Focal
Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas	Fneppk
Focal Nonepidermolytic Palmoplantar Keratoderma 1	Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1
Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1

Erythrokeratodermia Variabilis Et Progressiva 1

Erythrokeratodermia Variabilis	Erythrokeratodermia Variabilis Et Progressiva
Greither Disease	Ekv
Ekvp	PSEK
Erythrokeratodermia Variabilis With Erythema Gyratum Repens	Keratosis Palmoplantaris Transgrediens Et Progrediens
Transgrediens Et Progrediens Palmoplantar Keratoderma	EKVP1
Erythrokeratodermia, Progressive Symmetric	Erythrokeratodermia Figurata, Congenital Familial, In Plaques
Keratoderma Palmoplantaris Transgrediens	Keratosis Extremitatum Hereditaria Progrediens
Erythrokeratodermia Variabilis, Mendes Da Costa Type	Progressive Symmetric Erythrokeratodermia
Erythrokeratodermia Figurata Variabilis	Greither'S Disease
Ekv-P	Erythrokeratodermia Variabilis Of Mendes Da Costa
Progressive Symmetrical Erythrokeratoderma Of Gottron	Progressive Diffuse Ppk
Progressive Diffuse Palmoplantar Keratoderma	Transgrediens Et Progrediens Ppk
Darier-Gottron Disease	Erythrokeratodermia Progressiva Symmetrica
Progressive Symmetric Erythrokeratodermia, Gottron Type	Congenital Familial Erythrokeratodermia Figurata In Plaques
Erythrokeratodermia Progressive Symmetric	Erythrokeratodermia Variabilis Mendes Da Costa Type

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome	Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques
Palmoplantar And Periorificial Keratoderma	Olms

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13385	SLURP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SLURP1	VGNC	VGNC:81699
Rattus norvegicus	SLURP1	RGD	RGD:1308768
Bos taurus	SLURP1	VGNC	VGNC:34972
Canis familiaris	SLURP1	VGNC	VGNC:46516
Macaca mulatta	SLURP1	VGNC	VGNC:82242
Mus musculus	SLURP1	MGD	MGI:1930923

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLURP1 - secreted LY6/PLAUR domain containing 1 Gene

关于 SLURP1

功能概要

SLURP1 基因产物(1)

SLURP1 蛋白结构

SLURP1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

SLURP1 - secreted LY6/PLAUR domain containing 1 Gene

关于 SLURP1

功能概要

SLURP1 基因产物(1)

SLURP1 蛋白结构

SLURP1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z