2. Gene
  3. SMURF1 - SMAD specific E3 ubiquitin protein ligase 1 Gene

SMURF1 - SMAD specific E3 ubiquitin protein ligase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SMAD 特异性 E3 泛素蛋白连接酶 1

种属: Homo sapiens

基因 ID: 57154 | 基因类型: protein coding

关于 SMURF1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,027,440-99,144,108 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 206 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 21.9), stomach (RPKM 11.7) and 25 other tissues.

功能概要

该基因编码一种泛素连接酶，该连接酶对骨形态发生蛋白 (BMP) 通路中受受体调节的 SMAD 蛋白具有特异性。这种蛋白质在调节细胞运动、细胞信号传导和细胞极性方面起着关键作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2010 年 12 月]

This gene encodes a ubiquitin Ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]

SMURF1 基因产物(3)

mRNA Protein Name
NM_001199847.2 NP_001186776.1 E3 ubiquitin-protein ligase SMURF1 isoform 3
NM_020429.3 NP_065162.1 E3 ubiquitin-protein ligase SMURF1 isoform 1
NM_181349.3 NP_851994.1 E3 ubiquitin-protein ligase SMURF1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables I-SMAD binding IPI
IPI: 通过物理相互作用推断
11278251 GOA
enables R-SMAD binding IPI
IPI: 通过物理相互作用推断
11278251 GOA
enables activin receptor binding IPI
IPI: 通过物理相互作用推断
16720724 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15231748 GOA
enables transforming growth factor beta receptor binding IPI
IPI: 通过物理相互作用推断
12151385 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
11278251 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
10458166 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in BMP signaling pathway IDA
IDA: 通过直接分析推断
21572392 GOA
involved in cell differentiation IDA
IDA: 通过直接分析推断
10458166 GOA
involved in engulfment of target by autophagosome IMP
IMP: 通过突变表型推断
22020285 GOA
involved in negative regulation of BMP signaling pathway IDA
IDA: 通过直接分析推断
27214554 GOA
involved in negative regulation of activin receptor signaling pathway IDA
IDA: 通过直接分析推断
16720724 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
11278251 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
21791611 GOA
involved in positive regulation of dendrite extension IDA
IDA: 通过直接分析推断
23999003 GOA
involved in positive regulation of ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
21454619 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
11278251 GOA
involved in protein export from nucleus IDA
IDA: 通过直接分析推断
11278251 GOA
involved in protein localization to plasma membrane IDA
IDA: 通过直接分析推断
12151385 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
11278251 GOA
involved in protein targeting to vacuole involved in autophagy IMP
IMP: 通过突变表型推断
22020285 GOA
involved in receptor catabolic process IDA
IDA: 通过直接分析推断
12151385 GOA
involved in substrate localization to autophagosome IMP
IMP: 通过突变表型推断
22020285 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
10458166 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11278251 GOA
colocalizes with mitochondrion IGI
IGI: 通过遗传相互作用推断
22020285 GOA
is active in plasma membrane IDA
IDA: 通过直接分析推断
12151385 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SMURF1 蛋白结构

C2

C2: C2 domain (16 - 97)

WW

WW: WW domain (236 - 265)

WW

WW: WW domain (308 - 337)

HECT

HECT: HECT-domain (ubiquitin-transferase) (449 - 756)

  • 0
  • 200
  • 400
  • 600
  • 757 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase SMURF1

E3 ubiquitin ligase SMURF1

SMURF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SMURF1 Q9HCE7 SMAD1 Homo sapiens Q15797
Anti Tag CoIP
19914168
种属内
SMURF1 Q9HCE7 SMAD1 Homo sapiens Q15797
Y2H
15231748
种属内
SMURF1 Q9HCE7 PSME3 Homo sapiens P61289
Y2H
20580715
种属内
SMURF1 Q9HCE7 PSME3 Homo sapiens P61289
Pull Down
20580715
种属内
SMURF1 Q9HCE7 PSME3 Homo sapiens P61289
Anti Tag CoIP
20580715
种属内
SMURF1 Q9HCE7 FBXL15 Homo sapiens Q9H469
Y2H
21572392
种属内
SMURF1 Q9HCE7 FBXL15 Homo sapiens Q9H469
Anti Tag CoIP
21572392
种属内
SMURF1 Q9HCE7 FBXL15 Homo sapiens Q9H469
Anti Bait CoIP
21572392
种属内
SMURF1 Q9HCE7 PLEKHO1 Homo sapiens Q53GL0
Pull Down
20580715
种属内
SMURF1 Q9HCE7 PLEKHO1 Homo sapiens Q53GL0
Pull Down
23032291
种属内
SMURF1 Q9HCE7 KLF2 Homo sapiens Q9Y5W3
Y2H
21382345
种属间: 跨种属相互作用 种属内: 同种属相互作用

SMURF1 抗体

目录号 产品名 应用 反应物种
HY-P87078 SMURF1 Antibody (YA6771) WB Human

关联疾病

疾病名称 别名
Geotrichosis
Brachydactyly, Type A2

Brachydactyly Type A2

BDA2

Mohr-Wriedt Type Brachydactyly

Brachymesophalangy Ii

Brachymesophalangy Type 2

Brachymesophalangy 2

Brachydactyly, Mohr-Wriedt Type

Brachydactyly A2
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110195 Smurf1-IN-A01 99.81% 否
HY-149316 Smurf1-IN-1 Inhibitor 99.47% 否
HY-W998345 SMART1 Inhibitor 99.87% 否
HY-160928 Smurf1 modulator-1 Inhibitor 99.76% 否
HY-169049 Smurf1 ligand 1 / 否
HY-174416 Smurf1-IN-5 Inhibitor / 否
HY-RS13459 SMURF1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18717 Smurf1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25204 Smurf1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SMURF1 VGNC VGNC:77726
Rattus norvegicus SMURF1 RGD RGD:1594738
Mus musculus SMURF1 MGD MGI:1923038
Felis catus SMURF1 VGNC VGNC:65510
Bos taurus SMURF1 VGNC VGNC:35040
Canis familiaris SMURF1 VGNC VGNC:46580
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