ADGRG6 - adhesion G protein-coupled receptor G6 Gene

中文名称：粘附 G 蛋白偶联受体 G6

种属: Homo sapiens

同用名: APG1; DREG; VIGR; LCCS9; PR126; GPR126; PS1TP2

基因 ID: 57211 | 基因类型: protein coding

关于 ADGRG6

Cytogenetic location: 6q24.2 Genomic coordinates (GRCh38): 6:142,302,007-142,446,261 (from NCBI)

This gene has 14 transcripts (splice variants), 209 orthologues, 42 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 17.7), liver (RPKM 15.5) and 18 other tissues.

功能概要

该基因在人脐静脉内皮细胞中上调，编码 G 蛋白偶联受体。该基因的变异会影响一个人的身高。已发现该基因编码不同蛋白质的多个转录变体。[RefSeq 提供，2009 年 3 月]

This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009]

ADGRG6 基因产物(4)

mRNA	Protein	Name
NM_001032394.3	NP_001027566.2	adhesion G-protein coupled receptor G6 isoform alpha 2 precursor
NM_001032395.3	NP_001027567.2	adhesion G-protein coupled receptor G6 isoform beta 2 precursor
NM_020455.6	NP_065188.5	adhesion G-protein coupled receptor G6 isoform alpha 1 precursor
NM_198569.3	NP_940971.2	adhesion G-protein coupled receptor G6 isoform beta 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G protein-coupled receptor activity	IMP IMP: 通过突变表型推断	24227709	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Schwann cell differentiation	IMP IMP: 通过突变表型推断	24227709	GOA
involved in cAMP-mediated signaling	IMP IMP: 通过突变表型推断	24227709	GOA
involved in myelination	IMP IMP: 通过突变表型推断	26004201	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	15225624	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	15189448	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	15189448	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADGRG6 蛋白结构

CUB

Pentaxin

GPS

7tm_2

0
200
400
600
800
1000
1221 a.a.

蛋白主名

其他名称

adhesion G-protein coupled receptor G6

G-protein coupled receptor 126

关联疾病

疾病名称

别名

Lethal Congenital Contracture Syndrome 9

LCCS9

Contracture Syndrome, Lethal, Congenital, Type 9

Distal Arthrogryposis

Arthrogryposis Multiplex Congenita	Arthrogryposis
Congenital Multiple Arthrogryposis	Congenital Arthromyodysplasia
Fibrous Ankylosis Of Multiple Joints	Guerin-Stern Syndrome
Guérin-Stern Syndrome	Myodystrophia Fetalis Deformans
Otto Syndrome	Rocher-Sheldon Syndrome
Rossi Syndrome	Amc
Multiple Congenital Arthrogryposis	Arthrogryposis Syndrome
Arthrogryposis, Distal	Distal Arthrogryposis Syndrome
Freeman-Sheldon Syndrome	Arthrogryposis, Distal, Type 2b
Congenital Multiplex Arthrogryposis	Amyoplasia Congenita
Congenital Amyoplasia	Amc - [Arthrogryposis Multiplex Congenita]

Lethal Congenital Contracture Syndrome

Lccs	Lethal Congenital Contracture Syndrome 1

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria	BFPP
Cerebellar Ataxia With Neuronal Migration Defect

Celery Allergy

Arthrogryposis, Distal, Type 5

Oculomelic Amyoplasia	Distal Arthrogryposis Type 5
Distal Arthrogryposis Type Iib	DA5
Arthrogryposis With Oculomotor Limitation And Electroretinal Abnormalities	Daiib
Distal Arthrogryposis Type 2b	Arthrogryposis-Oculomotor Limitation-Electroretinal Anomalies Syndrome
Distal Arthrogryposis With Ophthalmoplegia	Arthrogryposis- Oculomotor Limitation-Electroretinal Anomalies Syndrome
Arthrogryposis, Distal, Type Iib	Da2b
Freeman-Sheldon Syndrome Variant	Sheldon-Hall Syndrome
Arthogryposis With Oculomotor Limitation And Electroretinal Abnormalities	Arthrogryposis Ophthalmoplegia Retinopathy
Arthrogryposis, Distal, 5	Arthrogryposis, Distal, Type 2b

Scoliosis

Combined Oxidative Phosphorylation Deficiency 5

COXPD5	Hypotonia With Lactic Acidemia And Hyperammonemia
Combined Oxidative Phosphorylation Defect Type 5	Combined Oxidative Phosphorylation Deficiency, Type 5

Lethal Congenital Contracture Syndrome 2

LCCS2	Lethal Congenital Contractural Syndrome 2
Multiple Contracture Syndrome, Israeli-Bedouin Type	Multiple Contracture Syndrome, Israeli Bedouin Type A
Multiple Contracture Syndrome, Israeli Bedouin Type	Lethal Congenital Contracture Syndrome Type 2
Israeli Bedouin Multiple Contracture Syndrome Type A	Contracture Syndrome, Lethal, Congenital, Type 2

Vegetable Allergy

Lethal Congenital Contracture Syndrome 4

LCCS4

Contracture Syndrome, Lethal, Congenital, Type 4

Idiopathic Scoliosis

Scoliosis Idiopathic

Vibratory Urticaria

Vibratory Angioedema	Dermodistortive Urticaria
VBU	Ddu
Angioedema, Vibratory

Usher Syndrome, Type Iic

Usher Syndrome Type 2c	USH2C
Usher Syndrome, Type 2c	Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic
Usher Syndrome Type Iic	Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic
Usher Syndrome 2c	Usher'S Syndrome Type 2c
Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic

Bone Structure Disease

Demyelinating Polyneuropathy

Peripheral Demyelinating Neuropathy

Demyelinating Peripheral Neuropathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-175232	GL64		/	否
HY-RS00359	ADGRG6 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21817	Adgrg6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS28333	Adgrg6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ADGRG6	RGD	RGD:1308551
Mus musculus	ADGRG6	MGD	MGI:1916151
Macaca mulatta	ADGRG6	VGNC	VGNC:81009
Canis familiaris	ADGRG6	VGNC	VGNC:37648
Felis catus	ADGRG6	VGNC	VGNC:102375
Bos taurus	ADGRG6	VGNC	VGNC:25669

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ADGRG6 - adhesion G protein-coupled receptor G6 Gene

关于 ADGRG6

功能概要

ADGRG6 基因产物(4)

ADGRG6 蛋白结构

关联疾病

直系同源

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ADGRG6 - adhesion G protein-coupled receptor G6 Gene

关于 ADGRG6

功能概要

ADGRG6 基因产物(4)

ADGRG6 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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