1. Gene
  2. CASKIN2 - CASK interacting protein 2 Gene

CASKIN2 - CASK interacting protein 2 Gene

中文名称:木桶相互作用蛋白 2

种属: Homo sapiens

同用名: ANKS5B

基因 ID: 57513 | 基因类型: protein coding

关于 CASKIN2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,500,261-75,515,537 (from NCBI)

This gene has 7 transcripts (splice variants), 270 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 13.1), lung (RPKM 12.8) and 24 other tissues.

功能概要

该基因编码的大蛋白包含六个锚蛋白重复序列,以及一个 Src 同源 3 (SH3) 结构域和两个不育 alpha 基序 (SAM) 结构域,这些结构域可能参与蛋白质-蛋白质相互作用。该蛋白的 C 端部分富含脯氨酸并包含一个保守区域。相关蛋白与钙/钙调蛋白依赖性丝氨酸蛋白激酶 (CASK) 相互作用。可变剪接导致多个转录本变体。[RefSeq 提供,2013 年 3 月]

This gene encodes a large protein that contains six ankyrin repeats, as well as a Src homology 3 (SH3) domain and two sterile alpha motif (SAM) domains, which may be involved in protein-protein interactions. The C-terminal portion of this protein is proline-rich and contains a conserved region. A related protein interacts with calcium/calmodulin-dependent serine protein kinase (CASK). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

CASKIN2 基因产物(2)

mRNA Protein Name
NM_001142643.3 NP_001136115.1 caskin-2 isoform b
NM_020753.5 NP_065804.2 caskin-2 isoform a

CASKIN2 蛋白结构

Ank_2

Ank_2: Ankyrin repeats (3 copies) (7 - 110)

Ank_4

Ank_4: Ankyrin repeats (many copies) (118 - 168)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (185 - 251)

SH3_2

SH3_2: Variant SH3 domain (286 - 344)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (490 - 549)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (561 - 619)

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  • 1202 a.a.
蛋白主名 其他名称

caskin-2

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CASKIN2 RGD RGD:1309738
Canis familiaris CASKIN2 VGNC VGNC:38731
Mus musculus CASKIN2 MGD MGI:2157062
Macaca mulatta CASKIN2 VGNC VGNC:70577
Felis catus CASKIN2 VGNC VGNC:60378
Bos taurus CASKIN2 VGNC VGNC:26778