2. Gene
  3. ADGRB2 - adhesion G protein-coupled receptor B2 Gene

ADGRB2 - adhesion G protein-coupled receptor B2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：粘附 G 蛋白偶联受体 B2

种属: Homo sapiens

同用名: BAI2

基因 ID: 576 | 基因类型: protein coding

关于 ADGRB2

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,727,117-31,764,340 (from NCBI)

This gene has 15 transcripts (splice variants), 199 orthologues and 42 paralogues. Biased expression in brain (RPKM 26.9), adrenal (RPKM 2.1) and 5 other tissues.

功能概要

该基因编码一种被认为是分泌素受体家族成员的七跨膜蛋白。编码的蛋白质是一种大脑特异性血管生成抑制剂。成熟肽可进一步切割成其他产物 (PMID:20367554) 。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 6 月]

This gene encodes a a seven-span transmembrane protein that is thought to be a member of the Secretin Receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

ADGRB2 基因产物(3)

mRNA Protein Name
NM_001294335.2 NP_001281264.1 adhesion G protein-coupled receptor B2 isoform 1 preproprotein
NM_001294336.2 NP_001281265.1 adhesion G protein-coupled receptor B2 isoform 2 preproprotein
NM_001364857.2 NP_001351786.1 adhesion G protein-coupled receptor B2 isoform 3 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IMP
IMP: 通过突变表型推断
28891236 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28891236 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
28891236 GOA
involved in calcineurin-NFAT signaling cascade IMP
IMP: 通过突变表型推断
28891236 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
28891236 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADGRB2 蛋白结构

TSP_1

TSP_1: Thrombospondin type 1 domain (314 - 361)

TSP_1

TSP_1: Thrombospondin type 1 domain (369 - 416)

TSP_1

TSP_1: Thrombospondin type 1 domain (424 - 471)

TSP_1

TSP_1: Thrombospondin type 1 domain (479 - 527)

(606 - 863)

GPS

GPS: GPCR proteolysis site, GPS, motif (871 - 917)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (931 - 1198)

  • 0
  • 300
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  • 900
  • 1200
  • 1585 a.a.
蛋白主名 其他名称

adhesion G protein-coupled receptor B2

brain-specific angiogenesis inhibitor 2

重组 ADGRB2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P79380 BAI2 Protein, Human (HEK293, hFc) O60241-3 (F21-D911) ≥95%

关联疾病

疾病名称 别名
Anal Carcinoma In Situ

Carcinoma In Situ Of Anal Canal

Carcinoma In Situ Of Anus

Anal Carcinoma Stage 0

Anal Intraepithelial Neoplasia Grade Iii

Intraepithelial Neoplasia Of Anal Canal, High Grade

Ain - [Anal Intraepithelial Neoplasia] High Grade
Vibratory Urticaria

Vibratory Angioedema

Dermodistortive Urticaria

VBU

Ddu

Angioedema, Vibratory
Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00346 ADGRB2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19763 Adgrb2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26260 Adgrb2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ADGRB2 VGNC VGNC:37634
Felis catus ADGRB2 VGNC VGNC:69074
Mus musculus ADGRB2 MGD MGI:2451244
Bos taurus ADGRB2 VGNC VGNC:25659
Rattus norvegicus ADGRB2 RGD RGD:1309431
Macaca mulatta ADGRB2 VGNC VGNC:69598
Others ADGRB2 NCBI
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