1. Gene
  2. POGK - pogo transposable element derived with KRAB domain Gene

POGK - pogo transposable element derived with KRAB domain Gene

中文名称:具有 KRAB 结构域的 pogo 转座子元件

种属: Homo sapiens

同用名: BASS2; KRBOX2; LST003

基因 ID: 57645 | 基因类型: protein coding

关于 POGK

Cytogenetic location: 1q24.1 Genomic coordinates (GRCh38): 1:166,839,475-166,856,359 (from NCBI)

This gene has 3 transcripts (splice variants), 187 orthologues and 11 paralogues. Ubiquitous expression in brain (RPKM 8.9), lung (RPKM 8.9) and 25 other tissues.

功能概要

该基因编码的蛋白质的确切功能尚不清楚。然而,该基因产物在 N 端包含一个 KRAB 结构域 (参与蛋白质-蛋白质相互作用) ,在 C 端包含一个转座酶结构域,表明它可能属于人类 DNA 介导的转座子家族.[RefSeq 提供,2008 年 7 月]

The exact function of the protein encoded by this gene is not known. However, this gene product contains a KRAB domain (which is involved in protein-protein interactions) at the N-terminus, and a transposase domain at the C-terminus, suggesting that it may belong to the family of DNA-mediated transposons in human. [provided by RefSeq, Jul 2008]

POGK 基因产物(2)

mRNA Protein Name
NM_001314014.2 NP_001300943.1 pogo transposable element with KRAB domain isoform 2
NM_017542.5 NP_060012.3 pogo transposable element with KRAB domain isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22939624 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

POGK 蛋白结构

KRAB

KRAB: KRAB box (49 - 87)

BrkDBD

BrkDBD: Brinker DNA-binding domain (195 - 247)

HTH_Tnp_Tc5

HTH_Tnp_Tc5: Tc5 transposase DNA-binding domain (260 - 322)

DDE_1

DDE_1: DDE superfamily endonuclease (356 - 567)

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  • 609 a.a.
蛋白主名 其他名称

pogo transposable element with KRAB domain

KRAB box domain containing 2

POGK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
POGK Q9P215 HSP90AB1 Homo sapiens P08238 22939624
种属内
POGK Q9P215 HSP90AB1 Homo sapiens P08238 22939624
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cervical Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Cervix

Adenosquamous Cell Carcinoma Of The Cervix Uteri

Non-Invasive Bladder Papillary Urothelial Neoplasm

Bladder Papillary Neoplasm Of Low Malignant Potential

Bladder Punlmp

Papillary Urothelial Neoplasm Of Low Malignant Potential

Papillary Transitional Cell Neoplasm Of Low Malignant Potential

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus POGK RGD RGD:1308951
Bos taurus POGK VGNC VGNC:33107
Macaca mulatta POGK VGNC VGNC:76066
Felis catus POGK VGNC VGNC:64278
Canis familiaris POGK VGNC VGNC:44768
Mus musculus POGK MGD MGI:1918842