2. Gene
  3. HCN3 - hyperpolarization activated cyclic nucleotide gated potassium channel 3 Gene

HCN3 - hyperpolarization activated cyclic nucleotide gated potassium channel 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：超极化激活环核苷酸门控钾通道 3

种属: Homo sapiens

基因 ID: 57657 | 基因类型: protein coding

关于 HCN3

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,277,463-155,289,848 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 343 orthologues and 17 paralogues. Ubiquitous expression in liver (RPKM 3.6), duodenum (RPKM 2.6) and 25 other tissues.

功能概要

该基因编码一种多通道膜蛋白，作为电压门控阳离子通道发挥作用。编码的蛋白质是密切相关的环磷酸腺苷结合通道蛋白家族的成员。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 8 月]

This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

HCN3 基因产物(1)

mRNA Protein Name
NM_020897.3 NP_065948.1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
26966193 GOA
enables voltage-gated potassium channel activity IDA
IDA: 通过直接分析推断
16043489 GOA
enables voltage-gated potassium channel activity IMP
IMP: 通过突变表型推断
22748890 GOA
enables voltage-gated sodium channel activity IDA
IDA: 通过直接分析推断
16043489 GOA
enables voltage-gated sodium channel activity IMP
IMP: 通过突变表型推断
22748890 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in cellular response to cAMP IDA
IDA: 通过直接分析推断
22748890 GOA
involved in potassium ion transmembrane transport IDA
IDA: 通过直接分析推断
16043489 GOA
involved in potassium ion transmembrane transport IMP
IMP: 通过突变表型推断
22748890 GOA
involved in regulation of membrane potential IMP
IMP: 通过突变表型推断
22748890 GOA
involved in sodium ion transmembrane transport IDA
IDA: 通过直接分析推断
16043489 GOA
involved in sodium ion transmembrane transport IMP
IMP: 通过突变表型推断
22748890 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
22748890 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HCN3 蛋白结构

Ion_trans_N

Ion_trans_N: Ion transport protein N-terminal (49 - 123)

Ion_trans

Ion_trans: Ion transport protein (129 - 344)

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (447 - 530)

  • 0
  • 200
  • 400
  • 600
  • 774 a.a.
蛋白主名 其他名称

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

关联疾病

疾病名称 别名
Bladder Neck Obstruction

Obstruction Of Bladder Neck Or Vesicourethral Orifice

Urinary Bladder Neck Obstruction

Bladder Outlet Obstruction

Vesicourethral Orifice Obstruction

Bno - [Bladder Neck Obstruction]

Bladder Obstruction Nos

Acquired Bladder Neck Obstruction

Acquired Obstruction Of Bladder Neck Or Vesicourethral Orifice

Bladder Neck Strangulation

Bladder Neck Stricture

Bladder Outflow Obstruction

Contracture Of Bladder Neck Or Sphincter

Contracture Of Bladder Neck

Obstructed Vesicourethral Orifice

Strangulation Of Vesicourethral Orifice

Stricture Of Vesicourethral Orifice

Urinary Prostatic Valve Obstruction

Vesical Obstruction
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-18940 Cilobradine / Phase 2
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13422 Zatebradine hydrochloride Antagonist 99.87% 否
HY-160505 RO-275 Inhibitor 99.0% 否
HY-13422A Zatebradine Antagonist 99.27% 否
HY-RS06048 HCN3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19140 Hcn3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20286 Hcn4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25631 Hcn3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris HCN3 VGNC VGNC:41621
Bos taurus HCN3 VGNC VGNC:29778
Mus musculus HCN3 MGD MGI:1298211
Macaca mulatta HCN3 VGNC VGNC:106379
Rattus norvegicus HCN3 RGD RGD:620691
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