2. Membrane Transporter/Ion Channel
  3. HCN Channel
  4. RO-275

RO-275 (compound 29) 是一种有效的选择性的和具有口服活性的 HCN1 抑制剂，对 HCN1、HCN2、HCN3、HCN4 的 IC50 值分别为 0.046、14.3、4.6、13.9 µM。RO-275 挽救工作记忆减退。RO-275 具有研究脑部疾病认知功能障碍的潜力。

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RO-275 Chemical Structure

RO-275 Chemical Structure

CAS No. : 2648837-04-9

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RO-275 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder[1][2].

IC50 & Target

IC50: 0.046 µM (HCN1); 14.3 µM (HCN2); 4.6 µM (HCN3); 13.9 µM (HCN4)[1]
体内研究
(In Vivo)

RO-275 (3, 10, 30 mg/kg; i.p.) 可挽救大鼠工作记忆减退[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats[2]
Dosage: 3, 10, 30 mg/kg
Administration: I.p.
Result: Improved performance in a translationally relevant touchscreen task of working memory (WM), tended to improve performance, but only at the longest delay of 6 s at the 10 mg/kg dose level, and led to a significant reduction in incorrect trials at 30 mg/kg in trial-unique, delayed non-matching-to-location (TUNL).
分子量

351.79

Formula

C18H14ClN5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RO-275 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

RO-2752648837-04-9RO275RO 275HCN ChannelHyperpolarization activated cyclic nucleotide gated channelssynapticworking memorybrain disorderInhibitorinhibitorinhibit

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