2. Gene
  3. Tbx21 - T-box 21 Gene

Tbx21 - T-box 21 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: TBT1; Tbet; Tblym

基因 ID: 57765 | 基因类型: protein coding

关于 Tbx21

功能概要

Enables DNA binding activity. Involved in several processes, including negative regulation of T-helper 17 cell lineage commitment; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of gene expression. Acts upstream of or within T cell differentiation; cellular response to organic substance; and positive regulation of isotype switching to IgG isotypes. Located in neuronal cell body and nucleus. Is expressed in several structures, including central nervous system; colon; genitourinary system; sensory organ; and thymus. Used to study asthma. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human TBX21 (T-box transcription factor 21). [provided by Alliance of Genome Resources, Apr 2022]

Tbx21 基因产物(1)

mRNA Protein Name
NM_019507.2 NP_062380.2 T-box transcription factor TBX21
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IMP
IMP: 通过突变表型推断
23616576 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10761931 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15662016 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within T cell differentiation IMP
IMP: 通过突变表型推断
20399120 MGI
involved in T-helper 1 cell lineage commitment IDA
IDA: 通过直接分析推断
10761931 MGI
involved in lymphocyte migration IMP
IMP: 通过突变表型推断
19805038 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
15662016 MGI
involved in negative regulation of T-helper 17 cell differentiation IDA
IDA: 通过直接分析推断
21151104 MGI
involved in negative regulation of T-helper 17 cell lineage commitment IMP
IMP: 通过突变表型推断
21151104 MGI
involved in negative regulation of T-helper 2 cell cytokine production IDA
IDA: 通过直接分析推断
10761931 MGI
involved in negative regulation of T-helper 2 cell cytokine production IMP
IMP: 通过突变表型推断
23616576 MGI
involved in negative regulation of interleukin-2 production IMP
IMP: 通过突变表型推断
23616576 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
21690296 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
15662016 MGI
involved in positive regulation of T-helper 1 cell cytokine production IDA
IDA: 通过直接分析推断
10761931 MGI
acts upstream of or within positive regulation of gene expression IGI
IGI: 通过遗传相互作用推断
22851706 MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes IMP
IMP: 通过突变表型推断
12882831 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10761931 MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
23616576 MGI
involved in regulation of T cell differentiation IMP
IMP: 通过突变表型推断
21690296 MGI
acts upstream of or within regulation of immune response IMP
IMP: 通过突变表型推断
12882831 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in neuronal cell body IDA
IDA: 通过直接分析推断
15677725 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15662016 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

T-box transcription factor TBX21

T-box protein 21

T-cell-specific T-box transcription factor T-bet

transcription factor TBLYM

Tbx21 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Tbx21 Q9JKD8 Runx1 Mus musculus Q03347
Anti Bait CoIP
21151104
种属内
Tbx21 Q9JKD8 Bcl6 Mus musculus P41183
Anti Bait CoIP
22406686
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14277 TBX21 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21062 Tbx21 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27579 Tbx21 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tbx21 NCBI NCBI:30009
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