1. Gene
  2. DLGAP3 - DLG associated protein 3 Gene

DLGAP3 - DLG associated protein 3 Gene

中文名称:DLG 相关蛋白 3

种属: Homo sapiens

同用名: DAP3; SAPAP3; SPAPA3

基因 ID: 58512 | 基因类型: protein coding

关于 DLGAP3

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:34,865,436-34,929,650 (from NCBI)

This gene has 3 transcripts (splice variants), 198 orthologues and 4 paralogues. Biased expression in brain (RPKM 6.5) and testis (RPKM 1.3).

功能概要

预计启用 PDZ 域绑定活动;分子衔接活性;和支架蛋白结合活性。预计参与含蛋白质的复合物组装和突触后神经递质受体活性的调节。预测位于突触中。预测为突触后密度的一部分。预计在几种细胞成分中具有活性,包括胆碱能突触;谷氨酸能突触;和神经肌肉接头。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable PDZ domain binding activity; molecular adaptor activity; and scaffold protein binding activity. Predicted to be involved in protein-containing complex assembly and regulation of postsynaptic neurotransmitter receptor activity. Predicted to be located in synapse. Predicted to be part of postsynaptic density. Predicted to be active in several cellular components, including cholinergic synapse; glutamatergic synapse; and neuromuscular junction. [provided by Alliance of Genome Resources, Apr 2022]

DLGAP3 基因产物(1)

mRNA Protein Name
NM_001080418.3 NP_001073887.1 disks large-associated protein 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17474147 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DLGAP3 蛋白结构

GKAP

GKAP: Guanylate-kinase-associated protein (GKAP) protein (625 - 979)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 979 a.a.
蛋白主名 其他名称

disks large-associated protein 3

DAP-3

DLGAP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DLGAP3 O95886 MAGEA6 Homo sapiens P43360 32296183
种属内
DLGAP3 O95886 MAGEA6 Homo sapiens P43360 32296183
种属内
DLGAP3 O95886 MAGEA6 Homo sapiens P43360 32296183
种属内
DLGAP3 O95886 KRTAP1-3 Homo sapiens Q8IUG1 32296183
种属内
DLGAP3 O95886 KRTAP1-3 Homo sapiens Q8IUG1 32296183
种属内
DLGAP3 O95886 KRTAP5-2 Homo sapiens Q701N4 32296183
种属内
DLGAP3 O95886 KRTAP5-2 Homo sapiens Q701N4 32296183
种属内
DLGAP3 O95886 KRTAP5-2 Homo sapiens Q701N4 32296183
种属内
DLGAP3 O95886 MAGI2 Homo sapiens Q86UL8-2 32296183
种属内
DLGAP3 O95886 MAGI2 Homo sapiens Q86UL8-2 32296183
种属内
DLGAP3 O95886 MAGI2 Homo sapiens Q86UL8-2 32296183
种属内
DLGAP3 O95886 KANK2 Homo sapiens Q63ZY3 32296183
种属内
DLGAP3 O95886 KANK2 Homo sapiens Q63ZY3 32296183
种属内
DLGAP3 O95886 KANK2 Homo sapiens Q63ZY3 32296183
种属内
DLGAP3 O95886 NCK1 Homo sapiens P16333 17474147
种属内
DLGAP3 O95886 GOLGA2 Homo sapiens Q08379 32296183
种属内
DLGAP3 O95886 GOLGA2 Homo sapiens Q08379 32296183
种属内
DLGAP3 O95886 GOLGA2 Homo sapiens Q08379 32296183
种属内
DLGAP3 O95886 DLG2 Homo sapiens Q15700 32296183
种属内
DLGAP3 O95886 DLG2 Homo sapiens Q15700 32296183
种属内
DLGAP3 O95886 DLG2 Homo sapiens Q15700 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Trichotillomania

TTM

Hair-Pulling Syndrome

Compulsive Hair Plucking

Hair Pulling Disorder

Impulse Control Disorder

Disruptive, Impulse Control, And Conduct Disorders

Body Dysmorphic Disorder

Dysmorphophobia

Body Dysmorphia

Dysmorphic Syndrome

Body Dysmorphic Disorders

Kleptomania

Pathological Stealing

Obsessive-Compulsive Disorder

OCD

Obsessive-Compulsive Disorder, Susceptibility To

Anancastic Neurosis

Obsessive Compulsive Disorder

Anankastic Neurosis

Obsessive-Compulsive Neurosis

Obsessive Compulsive Behavior

Tic Disorder

Tics

Behavioral Tic

Chronic Tic Disorder

Chronic Motor Or Vocal Tic Disorder

Tic Disorders

Tic Disorder

Tic Disorder Nos

Tic Nos

Tic Spasm Nos

Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome

Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type

Wilson-Turner Syndrome

WTS

Mrxs6

X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome

Mrxswt

Wilson-Turner X-Linked Mental Retardation Syndrome

Mental Retardation, X-Linked, Syndromic 6

Mental Retardation, X-Linked, With Gynecomastia And Obesity

Intellectual Disability, X-Linked, Syndromic 6

Intellectual Disability, X-Linked, With Gynecomastia And Obesity

Wilson Turner Intellectual Disability Syndrome

X-Linked Intellectual Disability - Gynecomastia - Obesity

Follicular Mucinosis

Alopecia Mucinosa

Mucinosis, Follicular

Dicarboxylic Aminoaciduria

Glutamate-Aspartate Transport Defect

Dicarboxylicaminoaciduria

DCBXA

Renal Aminoacidurias

Transient Tic Disorder
Obsessive-Compulsive Personality Disorder

Anankastic Personality Disorder

Obsessive-Compulsive Personality

Compulsive Personality Disorder

Ocpd

Obsessional Personality Disorder

Gilles De La Tourette Syndrome

Tourette Syndrome

Tourette Disorder

GTS

Ts

Gilles De La Tourette'S Syndrome

Motor-Verbal Tic Disorder

Guinon'S Disease

Psychogenic Tics

Tourette'S Syndrome

Chronic Motor And Vocal Tic Disorder

Td

Tourette'S Disease

Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

Combined Vocal And Multiple Motor Tic Disorder

Tic De La Tourette

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Syndromic X-Linked Intellectual Disability

X-Linked Syndromic Intellectual Disability

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Syndromic Intellectual Disability
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus DLGAP3 VGNC VGNC:28089
Mus musculus DLGAP3 MGD MGI:3039563
Macaca mulatta DLGAP3 VGNC VGNC:71998
Felis catus DLGAP3 VGNC VGNC:61515
Canis familiaris DLGAP3 VGNC VGNC:39981
Rattus norvegicus DLGAP3 RGD RGD:708349